About this Research Topic
The process of autophagy, a conserved mechanism throughout evolution, plays a crucial role in regulating cellular physiology. Additionally, it serves as a modulator of virus-host interactions. It is a two-edged sword. On one hand, it plays an important role in controlling antiviral responses against a wide range of viral infections. Conversely, viruses have developed various strategies to evade the autophagic apparatus and thwart the body's defence mechanisms. Upon viral infection, host cells rapidly trigger autophagy to break down virus particles and components, assisting the antiviral interferon response to prevent the virus from replicating. Subsequently, B and T cells are activated upon recognizing antigens from viruses. Notably, many viruses have developed the capacity to prevent autophagy to escape immune system reactions and breakdown. Moreover, some viruses hijack autophagosomes for self-replication or exploit autophagic pathways for virus particle maturation and release. It's interesting to note that different viruses employ distinct tactics to thwart selective autophagy.
This Research Topic aims to explore the complicated networks underlying virus-host interactions via autophagic factors and pathways, thus providing new understandings of the pathogenic mechanisms of viruses. This Research Topic primarily focuses on how host autophagic factors and pathways regulate viruses, whether they infect humans, animals, plants, and bacteria. In addition, research on viral proteins that help viruses evade antiviral responses by antagonizing cellular components is highly encouraged.
This Research Topic covers all aspects of the field, including the autophagy initiation, regulation, process, and outcome during viral infections. Additionally, it addresses several key questions of interest:
1. How does the autophagy initiate upon viral entry?
2. How do cellular and viral factors regulate the process of autophagy during viral infections?
3. Which factors are involved in the degradation of viral or cellular materials, and what impact does autophagy have on viral infections?
4. Delineate the networks underlying host-virus interactions that are necessary for autophagy.
5. Autophagy of immune cells during viral infections
This Research Topic aims to explore the complicated networks underlying virus-host interactions via autophagic factors and pathways, thus providing new understandings of the pathogenic mechanisms of viruses. This Research Topic primarily focuses on how host autophagic factors and pathways regulate viruses, whether they infect humans, animals, plants, and bacteria. In addition, research on viral proteins that help viruses evade antiviral responses by antagonizing cellular components is highly encouraged.
This Research Topic covers all aspects of the field, including the autophagy initiation, regulation, process, and outcome during viral infections. Additionally, it addresses several key questions of interest:
1. How does the autophagy initiate upon viral entry?
2. How do cellular and viral factors regulate the process of autophagy during viral infections?
3. Which factors are involved in the degradation of viral or cellular materials, and what impact does autophagy have on viral infections?
4. Delineate the networks underlying host-virus interactions that are necessary for autophagy.
5. Autophagy of immune cells during viral infections
Keywords: virus, autophagy, pathways, cellular response, interaction
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
