About this Research Topic
Obesity intensifies the detrimental effects of both diabetes and cancer, two formidable noncommunicable diseases that present significant health challenges. Individuals afflicted with diabetes, particularly those with type 2, face heightened susceptibility to certain forms of cancer, including those of the liver, pancreas, endometrium, colon, rectum, breast, and bladder. Numerous factors, such as advancing age, obesity, subpar nutrition, and a sedentary lifestyle, have all been identified as culprits that elevate the risk of both diabetes and an array of cancers.
A landmark discovery known as the Warburg effect, unveiled in 1930, showed that glucose serves as the predominant energy source for cancer cells. The intricate connection between diabetes and cancer is believed to be channeled through hyperinsulinemia, hyperglycemia, and inflammatory processes.
This Research Topic will feature research that sheds light on novel interconnections between diabetes, metabolic irregularities, and cancer. The revelations from these findings harbor the potential to pave the way for innovative and effective therapeutic strategies for those grappling with cancer, diabetes, or obesity.
We welcome Original Research, Reviews, Clinical Trials, Case Reports, and General Commentary articles. Potential areas of interest include, but are not limited to:
- Mechanisms of tumor development in obese and diabetic individuals
- Impact of obesity and diabetes on cancer treatment outcomes
- Metabolic connections between cancer and obesity or diabetes
- Impact of obesity and diabetes on cancer risk
- Early detection and screening strategies for cancer in obese and diabetic individuals
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
A landmark discovery known as the Warburg effect, unveiled in 1930, showed that glucose serves as the predominant energy source for cancer cells. The intricate connection between diabetes and cancer is believed to be channeled through hyperinsulinemia, hyperglycemia, and inflammatory processes.
This Research Topic will feature research that sheds light on novel interconnections between diabetes, metabolic irregularities, and cancer. The revelations from these findings harbor the potential to pave the way for innovative and effective therapeutic strategies for those grappling with cancer, diabetes, or obesity.
We welcome Original Research, Reviews, Clinical Trials, Case Reports, and General Commentary articles. Potential areas of interest include, but are not limited to:
- Mechanisms of tumor development in obese and diabetic individuals
- Impact of obesity and diabetes on cancer treatment outcomes
- Metabolic connections between cancer and obesity or diabetes
- Impact of obesity and diabetes on cancer risk
- Early detection and screening strategies for cancer in obese and diabetic individuals
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.
Keywords: Cancer, Diabetes, Obesity, Metastasis, Diet, Angiogenesis, Metabolism, Inflammation, Lipids, Glycolysis, T cells
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
