About this Research Topic
The immunotherapy of tumors aims to mobilize the patient's own immune system to eliminate tumor cells, thereby achieving therapeutic effects. Currently, the three main directions are immune checkpoint blocking therapy (such as PD-1/PD-L1 inhibitors), adoptive T cell therapy (TCR-T, CAR-T, TIL), and tumor vaccines. Although significant progress has been made in tumor immunotherapy, the overall response rate is less than 30%, and most patients experience issues such as poor treatment efficacy and drug resistance.
In order to improve efficacy and overcome drug resistance, research in recent years has mainly focused on exploring new tumor immunotherapy targets and enhancing existing immunotherapy efficacy plans, such as combined anti angiogenic and metabolic interventions. The complex and diverse metabolic changes in the immune microenvironment are important factors that directly affect the effectiveness of tumor immunotherapy and drug resistance. With the development of the field of immune metabolism, the important roles of pathways such as glucose metabolism, amino acid metabolism, nucleotide metabolism, and lipid metabolism in regulating immune function in tumor microenvironment (TME) have gradually been revealed. Further research on immune metabolism has increasingly revealed the regulatory role of TME tissue cell metabolism on the immune microenvironment, and the effects of immune cells cannot be achieved without the driving force of metabolic reprogramming. Metabolic reprogramming is also essential for maintaining self and body homeostasis of various types of immune cells. As a potential tumor treatment target, immune metabolism can not only improve the immunosuppressive microenvironment, but also combine with existing conventional anti-tumor therapies to greatly improve drug resistance and other issues, thereby enhancing the effectiveness of tumor treatment.
This research topic collects the latest research results on targeted tumor immunometabolic pathway therapy and gene signatures and their molecular mechanisms implicated in cancer biology, including targeted glucose metabolism, amino acid metabolism, nucleotide metabolism, and lipid metabolism, providing new ideas for developing the potential of immunometabolic targeted therapy and finding new targets.
We welcome Original Research Articles, Reviews, Clinical Cases and Mini Reviews. Topics of interest include, but are not limited to:
-Targeted glucose metabolism and immune enhancement
-Targeted amino acid metabolism and inhibition of immune escape
-Targeted Nucleotide Metabolism and Adenosine Pathway
-Targeted Lipid Metabolism and Immunophenotype Transformation
-Regulation of immune microenvironment by TME tissue cell metabolism
-Immunometabolic markers and drug targets
-New signature genes for targeted therapy
-New immunotherapy drugs and treatment strategies
-Immune cell metabolism reprogramming
-New signature genes for targeted therapy
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
In order to improve efficacy and overcome drug resistance, research in recent years has mainly focused on exploring new tumor immunotherapy targets and enhancing existing immunotherapy efficacy plans, such as combined anti angiogenic and metabolic interventions. The complex and diverse metabolic changes in the immune microenvironment are important factors that directly affect the effectiveness of tumor immunotherapy and drug resistance. With the development of the field of immune metabolism, the important roles of pathways such as glucose metabolism, amino acid metabolism, nucleotide metabolism, and lipid metabolism in regulating immune function in tumor microenvironment (TME) have gradually been revealed. Further research on immune metabolism has increasingly revealed the regulatory role of TME tissue cell metabolism on the immune microenvironment, and the effects of immune cells cannot be achieved without the driving force of metabolic reprogramming. Metabolic reprogramming is also essential for maintaining self and body homeostasis of various types of immune cells. As a potential tumor treatment target, immune metabolism can not only improve the immunosuppressive microenvironment, but also combine with existing conventional anti-tumor therapies to greatly improve drug resistance and other issues, thereby enhancing the effectiveness of tumor treatment.
This research topic collects the latest research results on targeted tumor immunometabolic pathway therapy and gene signatures and their molecular mechanisms implicated in cancer biology, including targeted glucose metabolism, amino acid metabolism, nucleotide metabolism, and lipid metabolism, providing new ideas for developing the potential of immunometabolic targeted therapy and finding new targets.
We welcome Original Research Articles, Reviews, Clinical Cases and Mini Reviews. Topics of interest include, but are not limited to:
-Targeted glucose metabolism and immune enhancement
-Targeted amino acid metabolism and inhibition of immune escape
-Targeted Nucleotide Metabolism and Adenosine Pathway
-Targeted Lipid Metabolism and Immunophenotype Transformation
-Regulation of immune microenvironment by TME tissue cell metabolism
-Immunometabolic markers and drug targets
-New signature genes for targeted therapy
-New immunotherapy drugs and treatment strategies
-Immune cell metabolism reprogramming
-New signature genes for targeted therapy
Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) will not be accepted in any of the sections of Frontiers in Oncology.
Keywords: Immunotherapy, immunometabolism, targeted therapy of immunometabolism, tumor microenvironment, gene expression signature
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
