About this Research Topic

Background

The intricate relationship between the human intestinal microbiome and its host holds a pivotal role in maintaining overall physiological health. With its remarkable capacity to produce a diverse array of bioactive molecules, the gut microbiome exerts a profound influence on various facets of human physiology. This encompasses the regulation of energy balance and metabolic pathways, as well as the development of the immune, endocrine, and nervous systems.

In recent years, significant strides in multi-omics data integration and the development of advanced bioinformatics tools have propelled the research landscape within the microbiome field. Nevertheless, the actual role of the human microbiome, along with the metabolites it produces, within the complex context of non-communicable diseases remains only partially understood. Critical questions regarding causal relationships and underlying mechanisms are yet to be fully unraveled. To address these knowledge gaps, there is a pressing need for in-depth investigations employing a translational approach that integrates data from animal models and clinical trials. This integration can unearth fundamental principles concerning microbial community structures and translate these findings into a rational design for increasingly effective and personalized microbiome-based interventions focused on reshaping dysbiotic profiles. The ultimate goal is to harness this knowledge for both the prevention and treatment of non-communicable diseases.

Furthermore, the utilization of computational models rooted in molecular mechanisms holds the potential to predict disease outcomes, treatment responses, and potential side effects. This, in turn, facilitates informed clinical decision-making. By weaving together the molecular mechanisms and molecular/cell biology with clinical practice, we aim to bridge the gap between cutting-edge research findings and tangible improvements in patient care, ultimately benefiting public health.

The objective of this Research Topic is to delve deep into the translational aspects of unraveling the gut microbiome and its far-reaching implications for non-communicable diseases such as, but not limited to, metabolic syndrome, obesity, diabetes, cardiovascular and hepatic diseases.

We welcome original research, clinical trials, reviews, and mini-reviews that contribute to our understanding of the gut microbiome's pivotal role in non-communicable diseases and, significantly, foster the translation of these findings into clinical practice. Authors are encouraged to submit manuscripts that explore among other themes:

• Patterns of dysbiosis and the role of microbial metabolites

• The identification of biomarkers closely associated with non-communicable diseases

• Translating microbiome-host interactions into effective disease-prevention strategies

• The development of predictive models for treatment response based on gut microbiome characteristics

• Personalized intervention strategies that target the gut microbiome

• The integration of multi-omics data and bioinformatics tools in gut microbiome research

Our Research Topic seeks to promote an open discussion of current mechanistic insights and innovative concepts, providing a panel for the publication of ground-breaking research that delves into the microbiome’s profound influences on non-communicable diseases, including but not limited to metabolic syndrome, obesity, diabetes, cardiovascular and hepatic diseases.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Conceptual Analysis
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Study Protocol
• Systematic Review
• Technology and Code

Keywords: gut microbiome, translational research, non-communicable diseases, metabolic syndrome, obesity, diabetes, hormone imbalance, cardiovascular disease, microbial metabolites, multi-omics, intervention strategies

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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