Advances in Brain Tumor Therapy

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Background

Brain tumors, a diverse group of neoplasms originating from abnormal cell growth within the brain or its surrounding structures, present complex diagnostic and therapeutic challenges. The diagnosis and treatment of brain tumors require a multidisciplinary approach, incorporating advanced imaging techniques, histopathology, molecular profiling, and innovative therapeutic interventions. Diagnostic imaging techniques, such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET), play a prominent role in assessing the tumor's location, size, and characteristics. Advanced imaging methods, such as functional MRI (fMRI) and diffusion tensor imaging (DTI), aid in identifying critical areas of the brain affected by the tumor and facilitating surgical planning.
Histopathology, immunohistochemistry, molecular testing, and genetic profiling have become integral to identifying specific molecular alterations that guide treatment decisions and predict the tumor's behavior and response to therapies. Additionally, gaining more information regarding novel concepts such as utilization of stem cells in prognosis, advancement in the novel therapeutic options, and mediation of intra-cellular signaling and metabolism related to tumor growth will lead to novel treatments. Integration of metabolic module along with molecular and morphological features could allow a deeper understanding of brain tumors and drive the pursuit of identification of emerging effective therapy options. With this Research Topic, we hope to consolidate novel diagnostic techniques, as well as emerging therapeutic options together could lead to the development of a robust, practical, and innovative take on life saving diagnostic and therapeutic options for individuals with brain tumors.

Differences in aggressiveness and growth rate in different types of tumors can complicate early diagnosis and the planning of effect and timely therapeutic plans. In fact, some brain tumors such as glioblastoma can be fatal in as little has six months if left untreated. Therefore, receiving timely diagnosis and intervention is crucial in the patient's prognosis.
Growing literature on aspects of brain tumors such as grown rates, environmental correlations, hereditary components, pharmacological and surgical interventions is promising. The overall goal of this issue is to is to consolidate novel diagnostic and therapeutic options to drive better prognosis for patients.


This special issue invites esteemed colleagues worldwide who are working in the field of neurooncology and related areas to submit original articles, and newly compiled literature reviews. Although work on pediatric tumors is vital, we would like to include work primarily done on adult primary brain tumors in this collection. Additionally, manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal. Subtopics we are interested in seeing work related to include but are not limited to:
• molecular mechanisms of tumor resistance,
• advanced therapies related to tumor targeting fields, immunotherapy, and vaccines,
• novel drug discoveries,
• advancement in utilization of stem cell,
• Imaging modalities,
• tumorigenesis (migration, proliferation, invasion),
• histopathologies
This special issue will give the authors an avenue to demonstrate their research to the international platform and will help their research to reach a wide audience in the world in hopes to drive early diagnostic methods and novel therapeutic options.

Keywords: Tumor microenvironment, cell-extracellular matrix interplay causing progression of pathology, tumor targeting fields (TTF), Biomarkers, Therapy resistance, Brain tumor stem cells, and Metabolism. Targeted therapy

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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