About this Research Topic
MicroRNAs (miRNAs) are small non-coding RNAs, approximately 22 nucleotides in length, that play a crucial role in regulating gene expression by targeting mRNAs for translational repression or degradation. Over the past three decades, significant progress has been made in understanding the biogenesis and function of miRNAs, with around 2,600 mature miRNAs identified in the human genome. These miRNAs have been extensively studied for their roles in central nervous system (CNS) homeostasis and pathophysiology. Recent research has highlighted the fundamental role of neuroinflammation in the development and progression of neurodegenerative diseases and stroke, with aging being a major risk factor due to its association with chronic, low-grade inflammation. Despite growing evidence linking miRNAs to neuroinflammation in neurodegenerative diseases and aging, their potential for diagnostic and therapeutic applications remains uncertain. This gap underscores the need for further investigation into the multifaceted roles of miRNAs in these processes.
This Research Topic aims to explore and provide new insights into the complex roles of miRNAs in neuroinflammation and brain aging. The focus will be on understanding the mechanisms that control immune cell activation and polarization, homeostasis, metabolism, synaptic plasticity, neurogenesis, neuronal apoptosis and necrosis, cellular senescence, and circadian rhythm. By delving into these areas, the research seeks to establish a solid foundation for developing novel preventive, diagnostic, and therapeutic strategies for neuroinflammation, neurodegenerative diseases, stroke, and the aging brain through the modulation and monitoring of miRNA expression.
To gather further insights into the regulation of neuroinflammation and brain aging by miRNAs, we welcome articles addressing, but not limited to, the following themes:
• Protective and/or pathogenic roles of miRNAs in neuroinflammation and neurodegenerative diseases
• Beneficial effects of exercise-induced miRNAs in neuroinflammation and brain health
• Mitochondrial miRNAs in neuroinflammation and metabolism
• miRNAs involved in neuronal necroptosis and apoptosis, and neuroinflammation
• miRNAs as biomarkers for neuroinflammation and neurological diseases
• miRNAs as aging biomarkers and as regulators of cellular senescence and lifespan
• miRNAs that regulate synaptic plasticity and neurogenesis by microglia
• Astrocytic miRNAs that regulate neuroinflammation and metabolism
• miRNAs associated with spinal cord injury and neural and axonal regeneration
• Progress and challenges in developing miRNAs as therapeutic and preventive agents in neuroinflammation, inflammaging and neurological diseases
The Topic Editors declare no competing interests with regard to the Research Topic subject.
This Research Topic aims to explore and provide new insights into the complex roles of miRNAs in neuroinflammation and brain aging. The focus will be on understanding the mechanisms that control immune cell activation and polarization, homeostasis, metabolism, synaptic plasticity, neurogenesis, neuronal apoptosis and necrosis, cellular senescence, and circadian rhythm. By delving into these areas, the research seeks to establish a solid foundation for developing novel preventive, diagnostic, and therapeutic strategies for neuroinflammation, neurodegenerative diseases, stroke, and the aging brain through the modulation and monitoring of miRNA expression.
To gather further insights into the regulation of neuroinflammation and brain aging by miRNAs, we welcome articles addressing, but not limited to, the following themes:
• Protective and/or pathogenic roles of miRNAs in neuroinflammation and neurodegenerative diseases
• Beneficial effects of exercise-induced miRNAs in neuroinflammation and brain health
• Mitochondrial miRNAs in neuroinflammation and metabolism
• miRNAs involved in neuronal necroptosis and apoptosis, and neuroinflammation
• miRNAs as biomarkers for neuroinflammation and neurological diseases
• miRNAs as aging biomarkers and as regulators of cellular senescence and lifespan
• miRNAs that regulate synaptic plasticity and neurogenesis by microglia
• Astrocytic miRNAs that regulate neuroinflammation and metabolism
• miRNAs associated with spinal cord injury and neural and axonal regeneration
• Progress and challenges in developing miRNAs as therapeutic and preventive agents in neuroinflammation, inflammaging and neurological diseases
The Topic Editors declare no competing interests with regard to the Research Topic subject.
Keywords: microRNAs; neurodegenerative disease; neuroinflammation; immune cells; neurogenesis; aging; stroke, microRNAs, neurodegenerative disease, neuroinflammation, immune cells, neurogenesis, aging, stroke
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