About this Research Topic
The field of biomacromolecules systems applied to medical implants for the release of therapeutic agents is rapidly evolving, driven by the increasing demand for advanced medical devices due to the aging global population. Medical implants, such as catheters, stents, and hip joints, are essential for replacing, aiding, or enhancing biological structures. However, their implantation through surgery carries inherent risks, including infections, inadequate healing, and complications exacerbated by immunosuppression from conditions like AIDS, cancer, and diabetes. Recent studies have highlighted the potential of biomacromolecules—large biomolecules such as proteins, nucleic acids, and polysaccharides—to serve as effective release systems for therapeutic agents, significantly mitigating postoperative risks. Despite these advancements, there remains a critical need for comprehensive research to optimize these systems, address biocompatibility issues, and enhance the efficacy of therapeutic agent delivery.
This research topic aims to explore the use of biomacromolecule systems in biomedical implants for the controlled release of therapeutic agents. The primary objectives include investigating the mechanisms by which biomacromolecules can be configured to release proteins, nucleic acids, genes, and antibacterial substances, and evaluating their effectiveness in reducing postoperative complications. Specific questions to be addressed include the optimal design of biomacromolecule-based drug delivery systems, the impact of surface modifications on implant performance, and the biological responses elicited by these advanced materials.
To gather further insights into the application of biomacromolecule systems in medical implants, we welcome articles addressing, but not limited to, the following themes:
- Drug delivery systems based on biomacromolecules
- Medical implants coated with biomacromolecules
- Surface modifications of medical implants with biomacromolecules
- In vitro and in vivo analysis of coated implants with biomacromolecules
- Tissue reaction to biomacromolecule systems
- Study of biointerfaces
- Modeling and simulations of biomacromolecules at interfaces
We welcome contributions (original research articles, short communications, reviews, mini-reviews, perspectives, and opinions) reporting on recent leading-edge research findings in areas that include, but are not necessarily limited to, the topics listed above.
This research topic aims to explore the use of biomacromolecule systems in biomedical implants for the controlled release of therapeutic agents. The primary objectives include investigating the mechanisms by which biomacromolecules can be configured to release proteins, nucleic acids, genes, and antibacterial substances, and evaluating their effectiveness in reducing postoperative complications. Specific questions to be addressed include the optimal design of biomacromolecule-based drug delivery systems, the impact of surface modifications on implant performance, and the biological responses elicited by these advanced materials.
To gather further insights into the application of biomacromolecule systems in medical implants, we welcome articles addressing, but not limited to, the following themes:
- Drug delivery systems based on biomacromolecules
- Medical implants coated with biomacromolecules
- Surface modifications of medical implants with biomacromolecules
- In vitro and in vivo analysis of coated implants with biomacromolecules
- Tissue reaction to biomacromolecule systems
- Study of biointerfaces
- Modeling and simulations of biomacromolecules at interfaces
We welcome contributions (original research articles, short communications, reviews, mini-reviews, perspectives, and opinions) reporting on recent leading-edge research findings in areas that include, but are not necessarily limited to, the topics listed above.
Keywords: Biomacromolecules, medical implants, controlled release, therapeutic agents, drug release
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
