Effects and Mechanisms of Bariatric Surgery in Relieving Obesity and Its Complications

As the living standard improves, the number of overweight and obese people is increasing globally, leading to a steady rise in the prevalence of obesity-related diseases, such as type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), hypertension, hyperlipidemia, obstructive sleep apnea-hypopnea syndrome (OSHAS), and polycystic ovary syndrome (PCOS). However, significant and sustained weight loss is often not achieved with improved diet and increased physical activity. Evidence showed that bariatric surgery can provide significant and sustained weight loss and effective relief of T2DM and obesity-related diseases. The underlying mechanisms may be related to gastrointestinal hormones, intestinal flora, circulating bile acids, systemic inflammation, brain-gut axis, immunity, and others. Even though Sleeve Gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB) have become the most dominant surgical procedures in the world, postoperative complications and postoperative recurrences still exist. We still encourage new surgical options or techniques to evaluate their effectiveness and safety. We also hope to obtain more studies on bariatric surgery for obesity-related diseases to provide clinical support and reveal the underlying mechanisms.

This Research Topic aims to provide new and strong evidence through clinical trials and basic research to improve the clinical effectiveness and security of bariatric surgery, and broaden our understanding of the impact of bariatric surgery on obesity and obesity-related diseases. Meanwhile, it seeks to explore the potential mechanisms of bariatric surgery to alleviate obesity-related diseases.

In this Research Topic, we encourage authors to submit original research, reviews, meta-analyses, and case reports, including but not limited to the following topics.
• Impact of bariatric surgery on obesity and related diseases (T2DM, NAFLD, Hyperlipidemia, hypertension, OSHAS, PCOS) and underlying mechanisms
• Effects and mechanisms of bariatric surgery on obesity-related cancers (breast cancer, endometrial cancer, ovarian cancer, esophageal adenocarcinoma, colorectal cancer, pancreatic cancer and renal cancer)
• The safety and efficacy of new surgical approaches or techniques for bariatric surgery
• Predictors affecting the impact of bariatric surgery on obesity and related diseases.

Special Note for authors:
To move forward our understanding of the effects and mechanisms underlying bariatric and metabolic surgery for obesity and its complications, please take a look at articles published within the previous Research Topic Bariatric and Metabolic Surgery for Obesity and Related Diseases: Effects and Mechanisms