Drug Discovery in Cancer Research: Success Stories and Open Challenges

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Articles

ORIGINAL RESEARCH

Published on 27 Feb 2025

Discovery of highly potent and novel LSD1 inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

Ye Hong
Yuting Wang
Ziyi Hao
Xingxia Zhang
Yejun Si
Guoqiang Lin
Shurong Zhang
Miao-Miao Niu
Xiaotian Yang
Yanming Zhang

doi 10.3389/fphar.2025.1510319

261 views

ORIGINAL RESEARCH

Published on 21 Feb 2025

Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting system database

Wanming He
Lihua Tong
Yanling Yuan
Xia Yang
Wen Yang
Xingxi Pan

doi 10.3389/fphar.2025.1448095

339 views

CASE REPORT

Published on 04 Feb 2025

Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report

Xiaoli Wang
Nan Wei
Huizhen Yang
Xiaoyan Wang
Xiaoju Zhang
Qianqian Zhang

doi 10.3389/fonc.2025.1487334

302 views

SYSTEMATIC REVIEW

Published on 08 Jan 2025

Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models

Marcelo Simonsen
Rossana Verónica Mendoza López
Simone Maistro
Lucas Takeshi Ikeoka
Glaucia Fernanda de Lima Pereira
Ademar Benévolo Lugão
José Carlos Sadalla
Maria Lúcia Hirata Katayama
Maria Aparecida Azevedo Koike Folgueira

doi 10.3389/fonc.2024.1487376

508 views

ORIGINAL RESEARCH

Published on 03 Jan 2025

Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

Wisam Taher Muslim
Layth Jasim Mohammad
Munaf M. Naji
Isaac Karimi
Matheel D. Al-Sabti
Majid Jabir
Mazin A. A. Najm
Helgi B. Schiöth

doi 10.3389/fphar.2024.1511627

678 views

ORIGINAL RESEARCH

Published on 12 Nov 2024

Efficacy and safety of regorafenib for the treatment of metastatic colorectal cancer in routine clinical practice: results from a Spanish hospital

Pilar Sotoca Rubio
Ana María Barrill Corpa
Víctor Alia Navarro
Patricia Pérez de Aguado Rodríguez
Jaime Moreno Doval
Juan Carlos Calvo Pérez
Patricia Guerrero Serrano
Carlos García Merino
Coral García de Quevedo Suero
5 more
Belén de Frutos González

doi 10.3389/fonc.2024.1446945

501 views

REVIEW

Published on 05 Nov 2024

PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

Sameh Saber
Rasha Abdelhady
Mai A. Elhemely
Elsayed A. Elmorsy
Rabab S. Hamad
Mustafa Ahmed Abdel-Reheim
Attalla F. El-kott
Mohammed A. AlShehri
Kareem Morsy
1 more
Mahmoud E. Youssef

doi 10.3389/fphar.2024.1475998

1,373 views

CASE REPORT

Published on 01 Nov 2024

Case report: Treatment with ensartinib shows good response to SQSTM1-ALK fusion in lung adenocarcinoma

Pandeng Wang
Zhuo Jiang
Jianji Guo
Tao Liu
Zhen Liu
Dongdong Wang
Honglin Li

doi 10.3389/fphar.2024.1433894

585 views

CASE REPORT

Published on 26 Sep 2024

A case report: deep and durable response to low-dose lenvatinib and tislelizumab in an elderly patient with advanced intrahepatic cholangiocarcinoma

Pei Zhang
Xin Wang
Ruizhen Li
Xiaoying Li
Ke Cheng
Dan Cao

doi 10.3389/fphar.2024.1447582

629 views

REVIEW

Published on 27 Aug 2024

Dual roles of inflammatory programmed cell death in cancer: insights into pyroptosis and necroptosis

Shuai Wang
Huanhuan He
Lailiang Qu
Qianhe Shen
Yihang Dai

doi 10.3389/fphar.2024.1446486

974 views
2 citations

ORIGINAL RESEARCH

Published on 21 Aug 2024

CAR-T therapy pulmonary adverse event profile: a pharmacovigilance study based on FAERS database (2017–2023)

Jing Shi
Xinya Liu
Yun Jiang
Mengjiao Gao
Jian Yu
Yuanming Zhang
Li Wu

doi 10.3389/fphar.2024.1434231

1,307 views

CASE REPORT

Published on 13 Aug 2024

Case report: Pyrotinib and tegafur combined with radiotherapy achieved notable response in HER2-amplified rectal cancer with multiple metastases after multiline treatments

Peng Huang
Feng Wen
Xin Wang

doi 10.3389/fphar.2024.1431542

637 views
1 citation

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Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs
Experimental Pharmacology and Drug Discovery

Participating Journals

Frontiers in Oncology
- Pharmacology of Anti-Cancer Drugs
- 3.5 impact factor
- 6.2 citescore

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Articles

Discovery of highly potent and novel LSD1 inhibitors for the treatment of acute myeloid leukemia: structure-based virtual screening, molecular dynamics simulation, and biological evaluation

Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting system database

Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report

Peritoneal chemotherapy delivery systems for ovarian cancer treatment: systematic review of animal models

Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

Efficacy and safety of regorafenib for the treatment of metastatic colorectal cancer in routine clinical practice: results from a Spanish hospital

PU-H71 (NSC 750424): a molecular masterpiece that targets HSP90 in cancer and beyond

Case report: Treatment with ensartinib shows good response to SQSTM1-ALK fusion in lung adenocarcinoma

A case report: deep and durable response to low-dose lenvatinib and tislelizumab in an elderly patient with advanced intrahepatic cholangiocarcinoma

Dual roles of inflammatory programmed cell death in cancer: insights into pyroptosis and necroptosis

CAR-T therapy pulmonary adverse event profile: a pharmacovigilance study based on FAERS database (2017–2023)

Case report: Pyrotinib and tegafur combined with radiotherapy achieved notable response in HER2-amplified rectal cancer with multiple metastases after multiline treatments

Frontiers in Pharmacology

Pharmacology of Anti-Cancer Drugs

Experimental Pharmacology and Drug Discovery

Participating Journals

Frontiers in Oncology

Pharmacology of Anti-Cancer Drugs