About this Research Topic
The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays a critical role in cancer progression and its therapeutic response. The TME is composed of various cell types, including tumor, stromal, and immune cells. These cells interact with each other in a complex manner to shape the TME and influence cancer progression. Recent advances in cancer immunotherapy have demonstrated the power of harnessing the immune system to fight cancer. However, many patients with solid malignancies do not respond to immunotherapy. This is often due to the presence of an immunosuppressive TME.
The overarching goal of this Research Topic is to investigate the regulation of the immune-TME in solid malignancies and identify epigenetic cancer-related pathways that can be targeted for therapeutic intervention. This Research Topic has the potential to lead to the development of novel and more effective therapies for patients with solid malignancies through unraveling the field of cancer immunotherapy. By targeting the immune-TME, we can overcome the major challenges of immunotherapy resistance and improve the outcomes for cancer patients.
Researchers are encouraged to submit Original Research articles, Reviews, Mini-reviews, Systematic Reviews, Case Reports, Perspectives, Short communications, Opinions, Study Protocols, and Methods relevant to this article collection that will cover topics such as (but not limited to):
1. Studies that characterize the composition and heterogeneity of the immune-TME in solid malignancies.
2. Studies that identify the players that have a crucial role in regulating the immune-TME in solid malignancies.
3. Reports investigating the mechanisms by which epigenetic mechanisms control the regulators of the immune-TME (e.g. T cells, Tregs, MDSCs, CAFs).
4. Studies that develop and validate novel epigenetic therapies that target the immune-TME to improve the efficacy of cancer immunotherapy.
5. Epigenomic profiling studies that identify the differentially-expressed epigenetic regulators in the immune-TME.
6. In-vivo animal studies that validate novel therapies targeting the immune-TME.
7. Clinical trials investigating novel therapeutics targeting genes involved in several cellular processes, including immune cell differentiation, function, and trafficking.
The overarching goal of this Research Topic is to investigate the regulation of the immune-TME in solid malignancies and identify epigenetic cancer-related pathways that can be targeted for therapeutic intervention. This Research Topic has the potential to lead to the development of novel and more effective therapies for patients with solid malignancies through unraveling the field of cancer immunotherapy. By targeting the immune-TME, we can overcome the major challenges of immunotherapy resistance and improve the outcomes for cancer patients.
Researchers are encouraged to submit Original Research articles, Reviews, Mini-reviews, Systematic Reviews, Case Reports, Perspectives, Short communications, Opinions, Study Protocols, and Methods relevant to this article collection that will cover topics such as (but not limited to):
1. Studies that characterize the composition and heterogeneity of the immune-TME in solid malignancies.
2. Studies that identify the players that have a crucial role in regulating the immune-TME in solid malignancies.
3. Reports investigating the mechanisms by which epigenetic mechanisms control the regulators of the immune-TME (e.g. T cells, Tregs, MDSCs, CAFs).
4. Studies that develop and validate novel epigenetic therapies that target the immune-TME to improve the efficacy of cancer immunotherapy.
5. Epigenomic profiling studies that identify the differentially-expressed epigenetic regulators in the immune-TME.
6. In-vivo animal studies that validate novel therapies targeting the immune-TME.
7. Clinical trials investigating novel therapeutics targeting genes involved in several cellular processes, including immune cell differentiation, function, and trafficking.
Keywords: immune-oncology, tumor microenvironment, solid malignancies, epigenetics, immune therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
