More than half of the patients admitted worldwide to intensive care need positive pressure ventilation (PPV). PPV is a lifesaving strategy in acute respiratory failure (ARF) and, regardless of the causes of ARF, PPV must, at the same time, be lung protective and guarantee adequate gas exchange.
Despite its importance, it is increasingly clear that PPV has not be intended as a therapeutical intervention but as a support technique “to buy” time while the lungs recover. PPV has been defined as “a necessary evil”: it is lifesaving but still harbors important side effects. The potential adverse effects of PPV on the lungs have been extensively studied and defined over the past decades so that the concept of VILI (Ventilator-induced lung injury) and the more recent concept of P-SILI (i.e., patient – self-inflicted lung injury) are now widely used.
Much has been done to focus on the effects of the PPV on the lung, however, losing sight on its systemic effects. To date, potential systemic complications of PPV have been largely underestimated. For example, what are the effects of PPV on kidney function, fluid balance and electrolytes? How relevant are these effects in the clinical scenario?
We believe that this holistic view of the effects of PPV in ARF patients will have a positive impact in the clinical outcomes. With this purpose we are delighted to offer a collection that brings together the most important aspects of the lung cross-talk during PPV ventilation in the ARF patient. This article collection will include Review, Mini Review, Hypothesis and Theory and Perspectives papers divided by sections:
● Brain
● Gut and microbiota
● Heart and hemodynamic
● Immune System
● Kidney
● Liver
● Lung-machine cross talk
The objective of each section will be to highlight relevant cross-talk among the respiratory system, respiratory support techniques and the rest of the body, this from a molecular, physiological, anatomical and clinical point of view. Fort the Lung-machine cross talk the aim will be to explore the effects of the machines (i.e., invasive, and non-invasive mechanical ventilation, extracorporeal membrane oxygenation, extracorporeal carbon dioxide removal) on the physiological mechanism of the lung.
Keywords:
Lung cross-talk, mechanical ventilation, positive pressure ventilation impact, multiple organ support, lung-kidney cross-talk, lung-liver cross-talk, lung machine cross-talk
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
More than half of the patients admitted worldwide to intensive care need positive pressure ventilation (PPV). PPV is a lifesaving strategy in acute respiratory failure (ARF) and, regardless of the causes of ARF, PPV must, at the same time, be lung protective and guarantee adequate gas exchange.
Despite its importance, it is increasingly clear that PPV has not be intended as a therapeutical intervention but as a support technique “to buy” time while the lungs recover. PPV has been defined as “a necessary evil”: it is lifesaving but still harbors important side effects. The potential adverse effects of PPV on the lungs have been extensively studied and defined over the past decades so that the concept of VILI (Ventilator-induced lung injury) and the more recent concept of P-SILI (i.e., patient – self-inflicted lung injury) are now widely used.
Much has been done to focus on the effects of the PPV on the lung, however, losing sight on its systemic effects. To date, potential systemic complications of PPV have been largely underestimated. For example, what are the effects of PPV on kidney function, fluid balance and electrolytes? How relevant are these effects in the clinical scenario?
We believe that this holistic view of the effects of PPV in ARF patients will have a positive impact in the clinical outcomes. With this purpose we are delighted to offer a collection that brings together the most important aspects of the lung cross-talk during PPV ventilation in the ARF patient. This article collection will include Review, Mini Review, Hypothesis and Theory and Perspectives papers divided by sections:
● Brain
● Gut and microbiota
● Heart and hemodynamic
● Immune System
● Kidney
● Liver
● Lung-machine cross talk
The objective of each section will be to highlight relevant cross-talk among the respiratory system, respiratory support techniques and the rest of the body, this from a molecular, physiological, anatomical and clinical point of view. Fort the Lung-machine cross talk the aim will be to explore the effects of the machines (i.e., invasive, and non-invasive mechanical ventilation, extracorporeal membrane oxygenation, extracorporeal carbon dioxide removal) on the physiological mechanism of the lung.
Keywords:
Lung cross-talk, mechanical ventilation, positive pressure ventilation impact, multiple organ support, lung-kidney cross-talk, lung-liver cross-talk, lung machine cross-talk
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.