Aging Epigenome and Longevity

The Aging epigenome refers to changes in epigenetics marks and modifications as a person ages. Epigenetics refers to modifications to DNA and its associated proteins that can influence gene expression without altering the underlying DNA sequence. DNA methylation patterns tend to change with age. Changes in histone marks can affect chromatin structure and gene expression during aging. Altered expression of non-coding RNAs can contribute to age-related changes in gene regulation and cellular function. Aging can lead to alterations in higher-order chromatin structures, affecting the accessibility of genes to transcription factors. Epigenetics clocks can predict age-related health outcomes and are a valuable tool for studying the aging epigenome. The aging epigenome is a complex and dynamic field of research, and understanding these epigenetic changes can shed light on the molecular mechanisms underlying aging and age-related diseases. Researchers are exploring how these epigenetic changes can be targeted for potential interventions to promote healthier aging.

Aging epigenome research aims to investigate the changes in epigenetic patterns that occur as an individual grows older. The epigenome refers to chemical modifications to the DNA and associated proteins that can influence gene expression without altering the underlying DNA sequence. Understanding how the epigenome changes with age is crucial in shedding light on the molecular mechanisms of aging and age-related diseases. Aging epigenome research seeks to unravel the intricate relationship between epigenetics and the aging process. By achieving these research goals, scientists aim to gain insights into the molecular basis of aging, improve our understanding of age-related diseases, and potentially develop strategies to promote healthier and longer lives. The main goals of this Research Topic are to improve the understanding of aging through an epigenetics perspective and potentially develop strategies for longevity.

We welcome submissions in the form of Original Articles, Review Articles, Mini-Reviews, and Opinion Pieces. that cover (but are not limited to) the following topics:

•Characterizing Age-Related Epigenetic Changes
•Identifying Biomarkers of Aging
•Understanding the Functional Consequences of epigenetics of aging
•Epigenetic Regulation of Longevity
•Epigenetic Mechanisms of Age-Related Diseases
•Lifestyle and Environmental Factors
•Epigenetic Therapies
•Cross-Generational Epigenetic Inheritance

Keywords: Aging, Epigenome, Epigenetics of aging, Aging Epigenome, Longevity

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.