DNA Damage, Repair and Mutagenesis: Targeting Cancer’s Achilles Heel

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ORIGINAL RESEARCH

Published on 10 Sep 2025

NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines

Rashmi R. Joshi
E. Gloria Sepulveda
F. Ester Lujan
Jacob M. DeVargas
Amanda K. Ashley

doi 10.3389/fonc.2025.1547899

1,043 views

REVIEW

Published on 07 Jan 2025

REV7: a small but mighty regulator of genome maintenance and cancer development

Lara R. Maggs
Mitch McVey

doi 10.3389/fonc.2024.1516165

1,941 views
1 citation

ORIGINAL RESEARCH

Published on 07 Oct 2024

POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma

Laura del Puerto-Nevado
María J. Fernández-Aceñero
Arancha Cebrián
Yuliia Fatych
Luis I. Díez-Valladares
Elia Pérez-Aguirre
Sofía de la Serna
Alejandra García-Botella
Javier Martínez-Useros
1 more
Pedro A. Mateos-Gómez

doi 10.3389/fonc.2024.1433179

1,578 views
1 citation

REVIEW

Published on 12 Sep 2024

Aldehyde-induced DNA-protein crosslinks- DNA damage, repair and mutagenesis

Thomas Blouin
Natalie Saini

doi 10.3389/fonc.2024.1478373

4,522 views
5 citations

MINI REVIEW

Published on 10 Jul 2024

Key molecular DNA damage responses of human cells to radiation

Chencheng Zhang
Jibin Liu
Jun Wu
Kamakshi Ranjan
Xiaopeng Cui
Xingdan Wang
Dianzheng Zhang
Shudong Zhu

doi 10.3389/fcell.2024.1422520

2,785 views
6 citations

ORIGINAL RESEARCH

Published on 14 May 2024

PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation

Asli Muvaffak
Kevin G. Coleman

doi 10.3389/fonc.2024.1380633

3,987 views
6 citations

ORIGINAL RESEARCH

Published on 22 Apr 2024

RFWD3 modulates response to platinum chemotherapy and promotes cancer associated phenotypes in high grade serous ovarian cancer

Sarah J. Taylor
Robert L. Hollis
Charlie Gourley
C. Simon Herrington
Simon P. Langdon
Mark J. Arends

doi 10.3389/fonc.2024.1389472

1,530 views
2 citations

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Frontiers in Oncology

Molecular and Cellular Oncology

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Frontiers in Cell and Developmental Biology
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Articles

NEK4 suppresses cell proliferation in BT20 triple-negative breast cancer cells by diminishing expression of cell cycle genes, while its depletion mitigates proliferation in other cell lines

REV7: a small but mighty regulator of genome maintenance and cancer development

POLQ immunostaining behaves as a prognostic factor for pancreatic carcinoma

Aldehyde-induced DNA-protein crosslinks- DNA damage, repair and mutagenesis

Key molecular DNA damage responses of human cells to radiation

PARP inhibitor synthetic lethality in ATM biallelic mutant cancer cell lines is associated with BRCA1/2 and RAD51 downregulation

RFWD3 modulates response to platinum chemotherapy and promotes cancer associated phenotypes in high grade serous ovarian cancer

Frontiers in Oncology

Molecular and Cellular Oncology

Participating Journals

Frontiers in Cell and Developmental Biology