Neuroanatomical and Molecular Biomarkers for Multiple Sclerosis Progression and Therapeutic Response

Multiple sclerosis (MS) is a complex disorder characterized by inflammation, demyelination and neurodegeneration, leading to a spectrum of motor, sensory, and cognitive impairments. Despite advancements in disease-modifying therapies, the heterogeneity of disease presentation poses significant challenges in clinical management. There is a growing need to develop effective biomarkers to better select the appropriate treatment, to detect early progression and to uncover new therapeutic targets. Understanding the underlying neuroanatomical and molecular mechanisms associated with disease pathogenesis is crucial for these objectives. This research topic seeks to contribute to the advancement of neuroanatomical and molecular biomarkers to achieve a more personalized diagnosis, prognosis, and therapeutic interventions for individuals affected by MS.

This proposed focus on "Neuroanatomical and molecular biomarkers for multiple sclerosis" aims to improve our knowledge of specific anatomical indicators and their relationship with molecular biomarkers, that can serve as reliable measures for tracking the progression of MS. By harnessing cutting-edge neuroimaging techniques and advanced analytical tools, this research endeavor seeks to identify brain and spinal cord changes associated with molecular biomarkers that precede clinical manifestations, providing valuable insights into the underlying pathological processes. The ultimate goal is to establish a comprehensive framework that integrates neuroanatomical and molecular biomarkers into routine clinical practice, facilitating early detection, accurate prognosis and personalized treatment strategies for individuals affected by this complex neurological disorder.

This Research Topic focuses on advancing the understanding of MS through the identification of neuroanatomical and molecular biomarkers for disease progression.

Information for authors: we invite original research articles, reviews and methodological papers addressing novel neuroimaging techniques for the detection and quantification of neuroanatomical changes in MS progression; identification and validation of specific neuroanatomical biomarkers that correlate with disease activity, severity and prognosis in MS; integrative approaches combining neuroanatomical data with clinical, genetic and immunological parameters; and longitudinal studies exploring the dynamic changes in neuroanatomical biomarkers over the course of MS progression and in response to therapeutic interventions. Manuscripts should adhere to the journal's formatting guidelines and ethical standards.