About this Research Topic
In the intricate landscape of liver tumor progression, the interplay between programmed cell death (PCD) and immune responses within the tumor microenvironment has gained substantial attention. This dynamic crosstalk encompasses multiple facets, including apoptosis, necroptosis, and ferroptosis, influencing the tumor immune response. Liver cancers, such as hepatocellular carcinoma (HCC), are notorious for their immunosuppressive microenvironment. Thus, deciphering the interconnections between PCD and immunity is vital for comprehending the complexity of liver tumor progression.
The primary objective of this Research Topic is to provide a comprehensive overview of the intricate interplay between programmed cell death and immunity in the liver tumor microenvironment. We aim to elucidate the diverse roles of various forms of PCD in shaping immune responses and tumor progression. This collection of articles will focus on characterizing the molecular and cellular mechanisms governing this crosstalk, with a long-term vision of fostering innovative therapeutic strategies for liver cancer. By bringing together experts and their insights, we aspire to accelerate our understanding of this complex relationship and pave the way for translational applications in liver tumor management.
Specifically, manuscripts focusing on the following suptopics are highly welcome:
● Apoptosis and its impact on liver tumor immunity.
● Necroptosis as a double-edged sword in liver cancer.
● The role of ferroptosis in liver tumor progression and immunosuppression.
● Immune checkpoint regulation in the context of liver PCD.
● Immune cell infiltration and PCD dynamics in liver tumors.
● PCD-targeted therapies for liver cancer immunomodulation.
● Novel biomarkers indicating the PCD-immunity nexus in liver tumors.
● Cross-validation of PCD-immunity relationships across liver cancer subtypes.
● Preclinical models and their implications for understanding PCD-immunity in liver tumors.
● Translational perspectives: PCD-immunity targeting in liver cancer therapeutics.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
The primary objective of this Research Topic is to provide a comprehensive overview of the intricate interplay between programmed cell death and immunity in the liver tumor microenvironment. We aim to elucidate the diverse roles of various forms of PCD in shaping immune responses and tumor progression. This collection of articles will focus on characterizing the molecular and cellular mechanisms governing this crosstalk, with a long-term vision of fostering innovative therapeutic strategies for liver cancer. By bringing together experts and their insights, we aspire to accelerate our understanding of this complex relationship and pave the way for translational applications in liver tumor management.
Specifically, manuscripts focusing on the following suptopics are highly welcome:
● Apoptosis and its impact on liver tumor immunity.
● Necroptosis as a double-edged sword in liver cancer.
● The role of ferroptosis in liver tumor progression and immunosuppression.
● Immune checkpoint regulation in the context of liver PCD.
● Immune cell infiltration and PCD dynamics in liver tumors.
● PCD-targeted therapies for liver cancer immunomodulation.
● Novel biomarkers indicating the PCD-immunity nexus in liver tumors.
● Cross-validation of PCD-immunity relationships across liver cancer subtypes.
● Preclinical models and their implications for understanding PCD-immunity in liver tumors.
● Translational perspectives: PCD-immunity targeting in liver cancer therapeutics.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: Programmed Cell Death, Tumor Microenvironment, Tumor Immunity, Liver, Cellular Crosstalk
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
