The Role of Mucosal Surfaces on Asthma and Respiratory Disease

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About this Research Topic

Background

Asthma and respiratory diseases continue to pose a significant global health burden. While much research has been dedicated to understanding the underlying mechanisms and developing effective treatments, the exact role of mucosal surfaces in these conditions remains a subject of intense investigation. Mucosal surfaces, including those of the respiratory tract, play a vital role in immune defense and maintaining homeostasis. The respiratory mucosa acts as the first line of defense against pathogens, allergens, and environmental pollutants. It not only facilitates gas exchange but also harbours a complex ecosystem of resident microbes and immune cells crucial for proper immune response. Mounting evidence suggests that alterations in mucosal surfaces can contribute to the development and progression of asthma and other respiratory diseases. Disruptions in the delicate balance between the respiratory epithelium, mucus production, and immune responses can lead to increased susceptibility to allergens, chronic inflammation, and airway remodelling. This research aims to delve deep into unravelling the intricate interplay between mucosal surfaces and respiratory diseases. By investigating the specific cellular and molecular mechanisms involved, this study seeks to identify potential therapeutic targets and develop innovative strategies for better management and treatment of asthma and respiratory diseases.

This research aims to investigate the role of mucosal surfaces in asthma and respiratory diseases by characterizing the cellular and molecular components of the respiratory tract's mucosal surfaces. The goals of this study include determining the impact of mucosal surface alterations on disease development, exploring the influence of environmental factors on mucosal surface health, and identifying therapeutic targets and innovative treatment strategies. By comprehensively understanding the structure and function of the respiratory epithelium, the composition of the mucus layer, and the immune cell population within the mucosal environment, this research seeks to unravel the intricate interplay between mucosal surfaces and these diseases. Furthermore, examining the effects of air pollutants, allergens, microbial exposures, and other environmental triggers will provide insights into mucosal barrier function, immune regulation, and disease susceptibility. Ultimately, the findings of this research will contribute to improving our understanding, prevention, and treatment of asthma and respiratory diseases.

This Research Topic accepts Original Research, Methods, Review and Mini-Review, Hypothesis & Theory, Clinical Trial, Perspective, Case Report, Brief Research Report, General Commentary, and Opinion articles. We welcome manuscripts focusing on, but not limited to, the following sub-topics related to the Mucosal Immunology of Asthma and Respiratory Allergic Disease:
• Investigate the impact of mucosal immune responses on disease and asthma progression
• Explore the role of mucosal surfaces in allergic sensitization and airway inflammation
• Analyze the composition and properties of the mucus layer in relation to disease and asthma severity
• Examine the influence of environmental factors on mucosal surface integrity and immune regulation
• Investigate the interactions between resident microbes and mucosal surfaces in disease and asthma development
• Identify genetic and epigenetic factors that contribute to mucosal alterations and disease susceptibility
• Investigate the therapeutic potential of targeting mucosal surface components for disease and asthma management
• Explore the role of mucosal surfaces in mediating host-pathogen interactions and respiratory infections
• Investigate the impact of respiratory mucosal surface alterations on lung function and airway remodelling
• Analyze the effectiveness of current interventions targeting mucosal surfaces in asthma and respiratory diseases.
• Utilising the mucosal surface to treat asthma and respiratory disease

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

  • Case Report
  • Classification
  • Clinical Trial
  • Editorial
  • General Commentary
  • Hypothesis and Theory
  • Methods
  • Mini Review
  • Opinion

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Keywords: The role of Mucosal Surfaces on Asthma and Respiratory Disease

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