About this Research Topic
Loss of dystrophin protein function causes abnormal division of muscle stem cells during muscle regeneration, resulting in abnormal regeneration, and makes myofibers vulnerable to mechanical stress during muscle contraction.
Recent research has led to the development of new treatments for DMD after the causative gene was identified more than 30 years ago. Translational research related to muscle stem cells has also yielded several clinical results that could be a potential treatment for DMD.
In this Research Topic, we will discuss the current progress of therapeutic approaches for DMD, including muscle stem cell therapy, exon skipping, gene therapy, gene editing, and other methods.
In addition, this Research Topic is to include recent developments in the field of the multi-cellular crosstalk between muscle stem cells and other cell types via high-resolution imaging techniques, system biology, proteomic approaches, and epigenetic modifications.
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Keywords: muscle fibres, myocytes, muscle stem cells, Duchenne muscular dystrophy
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