About this Research Topic
Neurological disease modeling has been rapidly advancing rapidly with the use of human induced pluripotent stem cells (hiPSCs). This powerful platform has unlocked new possibilities for understanding the mechanisms involved in neurodevelopmental disorders (NDDs). Despite the recent advances, several challenges remain to be addressed in order to obtain insight into the origin of these disorders. These include measuring neuronal excitation and inhibition (E/I) balance, identifying transcriptional dysregulation, understanding protein homeostasis and trafficking, and evaluating chromatin perturbation in NDDs. These endpoints are essential to understanding the pathophysiology of a disorder, which can be used to develop assays for drug screening, guide the timing of therapeutic interventions and help with identifying potential biomarkers. Challenges also include the trade-off in reproducibility and throughput between using simple systems with a single
cell type and more complex systems such as organoids.
In this Research Topic, Frontiers in Neuroscience is seeking to address advances in human iPSC technology including those enabled by recent developments in gene editing, co-culture systems, three-dimensional organoids, tissue engineering, microfluidic organ-chips, methods paper that include paradigms/preparations validated across laboratories and characterization of these models using advanced microscopy techniques, multielectrode arrays, and integration of multi-omics data.
We particularly welcome the submission of Original Research, Reviews, Methods, Case Reports and Perspective articles. Topics of interest include but are not limited to:
• Rare and ultra-rare genetic neurodevelopmental disorders
• Paradigms/preparation validated across laboratories
• Long-term cultures, co-culture systems and 3D brain organoids
• Microfluidics and Organ-on-a-Chip Systems
• Novel protocols and techniques for advanced imaging techniques, including optogenetics and High-Throughput Screening
• Integration of multi-omics data - Integrating data from genomics, transcriptomics, proteomics, and metabolomics
cell type and more complex systems such as organoids.
In this Research Topic, Frontiers in Neuroscience is seeking to address advances in human iPSC technology including those enabled by recent developments in gene editing, co-culture systems, three-dimensional organoids, tissue engineering, microfluidic organ-chips, methods paper that include paradigms/preparations validated across laboratories and characterization of these models using advanced microscopy techniques, multielectrode arrays, and integration of multi-omics data.
We particularly welcome the submission of Original Research, Reviews, Methods, Case Reports and Perspective articles. Topics of interest include but are not limited to:
• Rare and ultra-rare genetic neurodevelopmental disorders
• Paradigms/preparation validated across laboratories
• Long-term cultures, co-culture systems and 3D brain organoids
• Microfluidics and Organ-on-a-Chip Systems
• Novel protocols and techniques for advanced imaging techniques, including optogenetics and High-Throughput Screening
• Integration of multi-omics data - Integrating data from genomics, transcriptomics, proteomics, and metabolomics
Keywords: Stem cell models, Organoids, Imaging, Genome editing, Microfluidic devices
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
