About this Research Topic
This research topic will focus on the roles that macrophages play in tumor initiation and metastasis, and investigate the possibility of targeting their biology, as a putative therapeutic intervention.
There are still unmet needs in refractory cancers, and macrophages play critical roles in cancer malignancy. Among the various roles macrophages take on, this research topic will focus on those of cancer initiation and metastasis. Recent developments in Single cell RNA-seq analysis (including spatial transcriptomic analysis), lineage tracing techniques, genetic mouse models capable of targeted ablation of macrophage subtypes, and advances in vivo and intravital imaging systems can reveal the impact of macrophages on cancer cells in primary or metastatic sites.
We encourage submission of original research and review articles covering macrophages in cancer initiation, dissemination, metastasis, and therapeutics or new techniques or advances in in vivo models and analytic methods for studying these areas.
Keywords: Macrophage, tumor initiation, cancer metastasis, cancer prevention, refractory cancer
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.