About this Research Topic
Trauma is the leading cause of death in young individuals, and aberrant changes in hemostatic function greatly increase the risk of mortality in a subset of bleeding patients. To improve therapeutic options in traumatic hemorrhage and other etiologies of bleeding and coagulopathy, various processes must be better elucidated, improved, and innovated. This will require deeper understanding of patient hemostatic functional changes and their mechanisms, as well as a deeper understanding of current available biologics for hemostatic resuscitation, and development of novel therapeutics and adjuncts, which collectively fundamentally revolve around various biomaterials, consumables, and devices. Moreover, innovation is also needed with respect to both materials used throughout hemostatic resuscitation and the concomitant devices used to measure efficacy.
This Research Topic focuses on the models and approaches to study and improve hemostatic resuscitation, including but not limited to microfluidic models of hemostasis, ex vivo and in vivo models of transfusion and resuscitation, assessment of patient samples from various etiologies of bleeding, novel synthetic hemostatic products or adjuncts, and novel or improved manufacturing methods of blood products. The objective of this article collection is to provide a transformative and unique perspective in this space, covering the gamut of innovative science in the fields of transfusion medicine, hemostasis, trauma, and coagulopathy space.
Biomaterials are integral to every aspect of transfusion. This scope includes product storage, devices, novel and synthetic adjuncts, other therapeutics, drug delivery, and better understanding disease states in the context of trauma and other applicable acute coagulopathies and hemostatic disorders.
This topic welcomes, but is not limited to, short reports, original research, mini reviews, and reviews in the following research areas:
• Computational models of hemostasis and/or injury
• Biomaterial surfaces - study and engineering
• Microfluidic models of vessel injury and hemostasis
• In vivo, ex vivo, and in vitro models of transfusion and resuscitation
• Study of functional effects of acute and acquired coagulopathies in etiologies of bleeding
• Novel blood product or hemostatic adjuncts, including synthetic and pharmacological entities
• Optimization of blood product manufacturing and storage
• Study of trauma associated endothelialopathy and effects of hemostatic resuscitation on endothelium
This Research Topic focuses on the models and approaches to study and improve hemostatic resuscitation, including but not limited to microfluidic models of hemostasis, ex vivo and in vivo models of transfusion and resuscitation, assessment of patient samples from various etiologies of bleeding, novel synthetic hemostatic products or adjuncts, and novel or improved manufacturing methods of blood products. The objective of this article collection is to provide a transformative and unique perspective in this space, covering the gamut of innovative science in the fields of transfusion medicine, hemostasis, trauma, and coagulopathy space.
Biomaterials are integral to every aspect of transfusion. This scope includes product storage, devices, novel and synthetic adjuncts, other therapeutics, drug delivery, and better understanding disease states in the context of trauma and other applicable acute coagulopathies and hemostatic disorders.
This topic welcomes, but is not limited to, short reports, original research, mini reviews, and reviews in the following research areas:
• Computational models of hemostasis and/or injury
• Biomaterial surfaces - study and engineering
• Microfluidic models of vessel injury and hemostasis
• In vivo, ex vivo, and in vitro models of transfusion and resuscitation
• Study of functional effects of acute and acquired coagulopathies in etiologies of bleeding
• Novel blood product or hemostatic adjuncts, including synthetic and pharmacological entities
• Optimization of blood product manufacturing and storage
• Study of trauma associated endothelialopathy and effects of hemostatic resuscitation on endothelium
Keywords: Hemostasis, Blood Products, Transfusion, Hemostatic Resuscitation, Biomaterial Thrombogenicity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
