About this Research Topic
The Research Topic at hand investigates into the dynamic empire of nanomaterials and small molecule-enabled precision therapeutics and diagnostics. This multidisciplinary field seeks to harness the potential of nanotechnology to revolutionize the way we diagnose and treat a plethora of diseases, particularly those influenced by intricate molecular pathways and epigenetic modifications. Additional, it introduces tools and platforms at the molecular and nanoscale level, which provide unprecedented opportunities for targeted interventions. Engineered nanoparticles, nanocarriers, and nanoscale devices can be intricately designed to interact with cellular components at the molecular level. This precision facilitates enhanced drug delivery and specificity, minimizing off-target effects and maximizing therapeutic impact. Moreover, nanotechnology-driven diagnostic tools exhibit the potential to detect early epigenetic markers and molecular changes, facilitating timely interventions and personalized treatment strategies. The central aim of this research is to synergistically combine the potential of nanotechnology, epigenetics, and precision medicine. This involves the development of nanoscale drug delivery systems, personalized to target specific epigenetic pathways implicated in various diseases. By interfacing with complex cellular mechanisms, these systems hold the promise of unlocking new dimensions of therapeutic efficiency.
Furthermore, the research delves into the design and implementation of nanosensors, which hold the ability to sensitively and selectively identify bio markers, epigenetic marker, and molecular changes linked to disease progression. This paves the way for earlier and more accurate disease detection, ultimately translating to improved patient outcomes and potentially reducing the burden on healthcare systems. A basis of this research lies in understanding the dynamic interplay between nanomaterials, clinical therapeutics, and epigenetic regulatory mechanisms. This not only ensures the optimization of therapeutic efficacy but also aids in minimizing any potential adverse effects. Rigorous testing and validation, both in preclinical and clinical settings, form an integral part of this exploration, as the goal is to bridge the gap between promising laboratory findings and tangible healthcare solutions. In summation, the proposed research embodies the amalgamation of nanotechnology, drug therapeutics, diagnostics, and epigenetics. By unravelling the complexities of these fields and investigating their intersections, this research endeavors to reshape healthcare paradigms. The potential outcomes encompass more effective and personalized treatment strategies, coupled with innovative diagnostic tools, collectively motivated to enhance patient care and well-being.
The goal of the research is to bring together a collection of papers that individually and collectively used develop novel nanomaterials, small molecule or any agent for biomedical applications. Especially, to the development of Protein/polymer/peptide/polyphenol/small molecule/-based nanomaterials such as nanoparticles, or nanostructure for therapeutic siRNA/antisense oligonucleotide delivery and its mechanism especially disease progression pathway analysis, epigenetics pathway. In addition, new synthesis methods of nanoparticles are to use as potential biosensing tools for disease diagnosis and discovery of bio markers, and epigenetic marker etc. Besides, we are promoting to develop the new biomaterials such as carbon dots and quantum dots in the detection of disease macromolecules as fluorescence probes. The development of quantum/carbon dots as molecular markers and environmental tracers and heavy metals will create cancer-like disease. We will assist in the identification of novel nanoparticles for biosensor applications in a variety of biomolecules, including therapeutic proteins, nucleic acids, lipids, carbohydrates, and small molecule detection. Nanomaterials could also be used to diagnose a variety of pathogenic organisms such as viruses, bacteria, and their component as antigens. Not only nanomaterials but also small molecule/ chemotherapeutic drug and its application in disease progression, detection, and clinical implementation for therapeutic purpose will be highly encouraged.
We invite the submission of Original Research, Review, Mini Review, Perspective articles, report, case study on various themes such:
• Design and synthesis of peptide/small molecule self-assembly for antisense oligo-nucleic acid/ siRNA/ small molecule/ polyphenol/ approved drug for delivery.
• Approved small molecule for chemotherapy and disease progression.
• Small molecule synthesis, and its potential application as drug/sensor for biomedical application. Additionally, its mechanism in disease progression pathway.
• Nanoparticle/small molecule induce epigenetic pathway and disease progression in various disease such as cancer, and genetic diseases.
• Development of new nanoparticles for biosensor application in biomaterials research.
• Fluorescent nanoparticles/nanodots for bioimaging probe.
• QDs/CDs for antibiotics, hazardous materials tracing.
• Mechanistic study on polymer/peptide-based nano delivery system.
• Stability study of polymer/peptide nanocarrier.
• Polymer-based Nano hydrogel and its drug loading and slow-release application.
Furthermore, the research delves into the design and implementation of nanosensors, which hold the ability to sensitively and selectively identify bio markers, epigenetic marker, and molecular changes linked to disease progression. This paves the way for earlier and more accurate disease detection, ultimately translating to improved patient outcomes and potentially reducing the burden on healthcare systems. A basis of this research lies in understanding the dynamic interplay between nanomaterials, clinical therapeutics, and epigenetic regulatory mechanisms. This not only ensures the optimization of therapeutic efficacy but also aids in minimizing any potential adverse effects. Rigorous testing and validation, both in preclinical and clinical settings, form an integral part of this exploration, as the goal is to bridge the gap between promising laboratory findings and tangible healthcare solutions. In summation, the proposed research embodies the amalgamation of nanotechnology, drug therapeutics, diagnostics, and epigenetics. By unravelling the complexities of these fields and investigating their intersections, this research endeavors to reshape healthcare paradigms. The potential outcomes encompass more effective and personalized treatment strategies, coupled with innovative diagnostic tools, collectively motivated to enhance patient care and well-being.
The goal of the research is to bring together a collection of papers that individually and collectively used develop novel nanomaterials, small molecule or any agent for biomedical applications. Especially, to the development of Protein/polymer/peptide/polyphenol/small molecule/-based nanomaterials such as nanoparticles, or nanostructure for therapeutic siRNA/antisense oligonucleotide delivery and its mechanism especially disease progression pathway analysis, epigenetics pathway. In addition, new synthesis methods of nanoparticles are to use as potential biosensing tools for disease diagnosis and discovery of bio markers, and epigenetic marker etc. Besides, we are promoting to develop the new biomaterials such as carbon dots and quantum dots in the detection of disease macromolecules as fluorescence probes. The development of quantum/carbon dots as molecular markers and environmental tracers and heavy metals will create cancer-like disease. We will assist in the identification of novel nanoparticles for biosensor applications in a variety of biomolecules, including therapeutic proteins, nucleic acids, lipids, carbohydrates, and small molecule detection. Nanomaterials could also be used to diagnose a variety of pathogenic organisms such as viruses, bacteria, and their component as antigens. Not only nanomaterials but also small molecule/ chemotherapeutic drug and its application in disease progression, detection, and clinical implementation for therapeutic purpose will be highly encouraged.
We invite the submission of Original Research, Review, Mini Review, Perspective articles, report, case study on various themes such:
• Design and synthesis of peptide/small molecule self-assembly for antisense oligo-nucleic acid/ siRNA/ small molecule/ polyphenol/ approved drug for delivery.
• Approved small molecule for chemotherapy and disease progression.
• Small molecule synthesis, and its potential application as drug/sensor for biomedical application. Additionally, its mechanism in disease progression pathway.
• Nanoparticle/small molecule induce epigenetic pathway and disease progression in various disease such as cancer, and genetic diseases.
• Development of new nanoparticles for biosensor application in biomaterials research.
• Fluorescent nanoparticles/nanodots for bioimaging probe.
• QDs/CDs for antibiotics, hazardous materials tracing.
• Mechanistic study on polymer/peptide-based nano delivery system.
• Stability study of polymer/peptide nanocarrier.
• Polymer-based Nano hydrogel and its drug loading and slow-release application.
Keywords: Nanomaterials, Precision Therapeutics, Nanotechnology, Precision medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
