About this Research Topic
The field of pharmacology has witnessed remarkable advancements in recent years, especially the journey towards personalized medicine. The desired impact of pharmacological interventions is linked with the precise modulation of the bio-interface. The bio interface is the point of contact between biological and non-biological materials including pharmacological interventions. The fast evolution of advanced genomic and data processing tools in context with tuning/modulation of bio interface, has made it possible to develop customized diagnosis and treatment interventions according to the patient's genetic, molecular, and physiological profile. The pharmacological outcome, referring to the desired therapeutic effects or response to drugs and medication, is indeed intricately linked with the interactions that occurs at the bio-interface. This interaction plays a fundamental role in determining how drugs interact with their target. This interaction also determines the inconsistencies or lack of reproducibility in the therapeutic outcome of a specific drug in different sets of individuals. Over the last decade, our increasing understanding of the intricate interactions occurring at the bio-interface and its role in influencing the body’s response to different drug molecules and nanomaterials has shown promise to overcome the obstacles in successful translation of nanomedicines.
Emerging literature identifying the key factors behind bio-interface interactions and innovative engineering strategies for its modulation has shed light on the “invisible” barriers faced by different therapies. Like every field of science, the use of artificial intelligence, such as machine learning and deep-learning-based smart program, has not only helped in deciphering complex links within vast dataset to obtain meaningful insights but also enables the design of biological tools to get maximum output with minimum input.
Novel biomedical applications such as lab-on-chip to tissue engineering and regenerative medicine requiring smart bio-interfaces with targeted functionalities have become paramount. This paradigm draws from the principles of biophysics, biochemistry, materials physics and chemistry to achieve enhanced control over bio-interface interactions. As the genomic paradigm expands and data processing tools evolve further, the field of bio-interface tuning and engineering is evolving. Consequently, there is a growing demand for new materials and methods that exhibit improved biocompatibility, activity and mechanical strength to promote effective control, imaging and testing of bio interface, thus enabling the design of cutting-edge pharmacological interventions.
In this Research Topic, we invite submissions focusing on recent advances in different aspects of bio-interface modulation and the interaction with bio/nanomaterials with the ultimate aim of improving pharmacological outcomes to address current and upcoming health challenges. The Research Topic welcomes original research and review articles focusing on, but not limited to, the following themes:
• Advancements in tools for the synthesis, characterization, optimization, or evaluation of bio-interface interactions. For example, optimizing the response (desirable or undesirable) toward selected cells population (e.g., normal human cells, cancer cells, immune cells, cells in nanoparticles clearing organs, bacteria, and other microorganisms)
• Structural aspects of nano/biomaterials for bio-interface interaction: Investigations into the morphology, porosity, and roughness of nano/biomaterials to understand their interactions with the bio-interface and optimize their performance
• Designing of nano/biomaterials for antimicrobial, anticancer and anti-inflammatory applications
• Biochemical considerations: Focus on molecular specificity, bio-orthogonality, and multifunctionality in the design of bio-interfaces, enabling precise and tailored pharmacological interventions
• Investigation of coating materials used for bio-interfaces, spanning from natural minerals to synthetic ones like different polymers
• Exploring Bio-Interface Modulation for the Sustainable Development of Eco-Friendly Pharmacological Agents
Emerging literature identifying the key factors behind bio-interface interactions and innovative engineering strategies for its modulation has shed light on the “invisible” barriers faced by different therapies. Like every field of science, the use of artificial intelligence, such as machine learning and deep-learning-based smart program, has not only helped in deciphering complex links within vast dataset to obtain meaningful insights but also enables the design of biological tools to get maximum output with minimum input.
Novel biomedical applications such as lab-on-chip to tissue engineering and regenerative medicine requiring smart bio-interfaces with targeted functionalities have become paramount. This paradigm draws from the principles of biophysics, biochemistry, materials physics and chemistry to achieve enhanced control over bio-interface interactions. As the genomic paradigm expands and data processing tools evolve further, the field of bio-interface tuning and engineering is evolving. Consequently, there is a growing demand for new materials and methods that exhibit improved biocompatibility, activity and mechanical strength to promote effective control, imaging and testing of bio interface, thus enabling the design of cutting-edge pharmacological interventions.
In this Research Topic, we invite submissions focusing on recent advances in different aspects of bio-interface modulation and the interaction with bio/nanomaterials with the ultimate aim of improving pharmacological outcomes to address current and upcoming health challenges. The Research Topic welcomes original research and review articles focusing on, but not limited to, the following themes:
• Advancements in tools for the synthesis, characterization, optimization, or evaluation of bio-interface interactions. For example, optimizing the response (desirable or undesirable) toward selected cells population (e.g., normal human cells, cancer cells, immune cells, cells in nanoparticles clearing organs, bacteria, and other microorganisms)
• Structural aspects of nano/biomaterials for bio-interface interaction: Investigations into the morphology, porosity, and roughness of nano/biomaterials to understand their interactions with the bio-interface and optimize their performance
• Designing of nano/biomaterials for antimicrobial, anticancer and anti-inflammatory applications
• Biochemical considerations: Focus on molecular specificity, bio-orthogonality, and multifunctionality in the design of bio-interfaces, enabling precise and tailored pharmacological interventions
• Investigation of coating materials used for bio-interfaces, spanning from natural minerals to synthetic ones like different polymers
• Exploring Bio-Interface Modulation for the Sustainable Development of Eco-Friendly Pharmacological Agents
Keywords: Bio-Interface, nanomaterials, biomaterials, pharmacological outcomes, personalized medicine
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
