Research Progress and Clinical Application of Brain Disorders Based on Fusion Multimodal Imaging and Neurogenomics: Early Diagnosis, Neuromodulation and Machine Learning Vol II

  • 810

    Total downloads

  • 3,829

    Total views and downloads

Submit your idea

You will be redirected to our submission process.

Submit your manuscript summarySubmit your manuscript

About this Research Topic

Submission closed

Background

Brain diseases are caused by lesions in the brain that lead to symptoms of corresponding neurological deficits. These diseases can be broadly classified into cerebrovascular diseases, inflammatory diseases, intracranial space-occupying lesions, hydrocephalus, cerebral parasitic diseases, extrapyramidal disorders, epilepsy, and cranial trauma. The study of brain diseases can involve the cross-fertilization of several disciplines, including genomics, molecular medicine, brain imaging, brain networks and machine learning. Advances in the sequencing technology helped us understand genetic alterations accurately, quickly, and cheaply, and gain a more fundamental and mechanistic understanding of brain disorders. In the meantime, multimodal imaging technology, a method of fusing image data from different imaging techniques (CT, MRI, PET, SPECT) to improve the accuracy and reliability of diagnostic imaging, provided a basis for the study of brain cognitive mechanisms and are also applied to assess structural and functional brain abnormalities in patients. Imaging technology and artificial intelligence allowed us to noninvasively visualize the brain structure, understand the brain network and strengthen the cognition of the brain. By exploring their mechanisms, the studies of brain disorders can provide potential novel biomarkers for diagnosis genuinely. They should be carried out from microscale to macroscale, from structure to function, from node to brain network.

Currently, diagnostic and therapeutic approaches to brain disorders are mainly derived from a number of relatively well-established randomised controlled trials and behavioural studies. But the understanding of their underlying mechanisms is not yet systematic or comprehensive, and lacks major breakthroughs. Hence, there is a need to further explore the underlying mechanisms of brain disorders by combining the above-mentioned approaches. Based on different perspectives and multidisciplinary intersections, we need a new understanding of brain diseases.

This Research Topic will focus on the potential mechanisms of brain diseases from the aspects of neurogenomics, signaling pathways, molecular mechanisms, using multimodal imaging genomics, neuromodulation and machine learning approaches, with a goal to provide new perspectives and approaches to study the underlying mechanisms and therapeutic targets of their pathogenesis, and closely integrates basic and clinical research to further enhance our understanding of brain diseases. We welcome contributions to the advances in the understanding of brain diseases and their related disorders in the respects of neurogenomics, multimodal imaging genomics, cell biology, signaling pathways, molecular mechanisms and neuromodulation. Besides traditional animal models and in vitro approaches, studies utilizing statistical and bioinformatics methods covering machine learning and other libraries and toolkits of algorithms based on histologic data are also welcome.

We welcome submissions of research and review articles on themes including but not limited to the following,

 Alteration of brain disorders and related conditions in molecular and cellular level.
 New perspectives on the diagnosis of brain diseases and related disorders.
 Functional neurocognition and diagnosis of brain diseases based on multimodal neurofunctional imaging.
 Multi-omics studies identifying pathogenic mechanisms and potential therapeutic targets for brain diseases and related disorders with mechanistic proofs
 Pathophysiological mechanisms of neurodegeneration in brain diseases and related disorders, with identified novel signaling pathways and molecular mechanisms.
 The etiology and pathogenesis of brain diseases uncovered using brain imaging techniques, to explore the link between structural and functional changes in early brain diseases, on pathophysiologic pathogenesis.
 New hypotheses or insights into the etiology or pathogenesis of brain diseases based on machine learning and other statistical methods, with proof from mechanistic study

Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.

Keywords: Brain Disorders, fusion multimodal, neurogenomics imaging, Neuromodulation, machine learning

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

Frequently asked questions

  • Frontiers' Research Topics are collaborative hubs built around an emerging theme.Defined, managed, and led by renowned researchers, they bring communities together around a shared area of interest to stimulate collaboration and innovation.

    Unlike section journals, which serve established specialty communities, Research Topics are pioneer hubs, responding to the evolving scientific landscape and catering to new communities.

  • The goal of Frontiers' publishing program is to empower research communities to actively steer the course of scientific publishing. Our program was implemented as a three-part unit with fixed field journals, flexible specialty sections, and dynamically emerging Research Topics, connecting communities of different sizes and maturity.

    Research Topics originate from the scientific community. Many of our Research Topics are suggested by existing editorial board members who have identified critical challenges or areas of interest in their field.

  • As an editor, Research Topics will help you build your journal, as well as your community, around emerging, cutting-edge research. As research trailblazers, Research Topics attract high-quality submissions from leading experts all over the world.

    A thriving Research Topic can potentially evolve into a new specialty section if there is sustained interest and a growing community around it.

  • Each Research Topic must be approved by the specialty chief editor, and it falls under the editorial oversight of our editorial boards, supported by our in-house research integrity team. The same standards and rigorous peer review processes apply to articles published as part of a Research Topic as for any other article we publish.

    In 2023, 80% of the Research Topics we published were edited or co-edited by our editorial board members, who are already familiar with their journal's scope, ethos, and publishing model. All other topics are guest edited by leaders in their field, each vetted and formally approved by the specialty chief editor.

  • Publishing your article within a Research Topic with other related articles increases its discoverability and visibility, which can lead to more views, downloads, and citations. Research Topics grow dynamically as more published articles are added, causing frequent revisiting, and further visibility.

    As Research Topics are multidisciplinary, they are cross-listed in several fields and section journals – increasing your reach even more and giving you the chance to expand your network and collaborate with researchers in different fields, all focusing on expanding knowledge around the same important topic.

    Our larger Research Topics are also converted into ebooks and receive social media promotion from our digital marketing team.

     

  • Frontiers offers multiple article types, but it will depend on the field and section journals in which the Research Topic will be featured. The available article types for a Research Topic will appear in the drop-down menu during the submission process.

    Check available article types here 

  • Yes, we would love to hear your ideas for a topic. Most of our Research Topics are community-led and suggested by researchers in the field. Our in-house editorial team will contact you to talk about your idea and whether you’d like to edit the topic. If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. 

    Suggest your topic here 

  • A team of guest editors (called topic editors) lead their Research Topic. This editorial team oversees the entire process, from the initial topic proposal to calls for participation, the peer review, and final publications.

    The team may also include topic coordinators, who help the topic editors send calls for participation, liaise with topic editors on abstracts, and support contributing authors. In some cases, they can also be assigned as reviewers.

  • As a topic editor (TE), you will take the lead on all editorial decisions for the Research Topic, starting with defining its scope. This allows you to curate research around a topic that interests you, bring together different perspectives from leading researchers across different fields and shape the future of your field. 

     

    You will choose your team of co-editors, curate a list of potential authors, send calls for participation and oversee the peer review process, accepting or recommending rejection for each manuscript submitted.

  • As a topic editor, you're supported at every stage by our in-house team. You will be assigned a single point of contact to help you on both editorial and technical matters. Your topic is managed through our user-friendly online platform, and the peer review process is supported by our industry-first AI review assistant (AIRA).

  • If you’re an early-stage researcher, we will offer you the opportunity to coordinate your topic, with the support of a senior researcher as the topic editor. This provides you with valuable editorial experience, improving your ability to critically evaluate research articles and enhancing your understanding of the quality standards and requirements for scientific publishing, as well as the opportunity to discover new research in your field, and expand your professional network.

  • Yes, certificates can be issued on request. We are happy to provide a certificate for your contribution to editing a successful Research Topic.

  • Research Topics thrive on collaboration and their multi-disciplinary approach around emerging, cutting-edge themes, attract leading researchers from all over the world.

  • As a topic editor, you can set the timeline for your Research Topic, and we will work with you at your pace. Typically, Research Topics are online and open for submissions within a few weeks and remain open for participation for 6 – 12 months. Individual articles within a Research Topic are published as soon as they are ready.

    Find out more about our Research Topics

  • Our fee support program ensures that all articles that pass peer review, including those published in Research Topics, can benefit from open access – regardless of the author's field or funding situation.

    Authors and institutions with insufficient funding can apply for a discount on their publishing fees. A fee support application form is available on our website.

  • In line with our mission to promote healthy lives on a healthy planet, we do not provide printed materials. All our articles and ebooks are available under a CC-BY license, so you can share and print copies.

     

Impact

  • 3,829Topic views
  • 2,352Article views
  • 810Article downloads
View impact