Applications of Nuclear Magnetic Resonance Spectroscopy in Biopharmaceuticals

Nuclear magnetic resonance (NMR) spectroscopy is a powerful characterization tool used to probe the structure of molecules with atomic-level information. NMR is especially useful in the biopharmaceutical industry, providing molecular, structural, and dynamic information to small, milla-, macro-, and biomolecules, as well as their metabolites and impurities. It can provide in-depth understanding of pharmaceutical formulations, excipients, and intermolecular interactions, thereby aiding in product development across large, milla-, and small molecules.

The goal of the present Research Topic is to spotlight recent advances in the applications of NMR in biopharmaceutical research spanning across molecular modalities and formulations from discovery chemistry to manufacturing, pharmaceutical product development, and quality control. We welcome original research, mini-reviews, and perspective articles that explore recent advances in the applications of NMR spectroscopy in biopharmaceutical drug delivery and design.

Topics can include:

1. Small molecule discovery
2. Metabolomics
3. Application in product development
4. Aiding manufacturing
5. Counterfeits
6. Quality control
7. Time-domain NMR applications
8. High-order structures in Biologics
9. Pharmaceutical excipients
10. Drug delivery

Keywords: NMR, Biopharmaceuticals, Drug Design, Drug Delivery, Across Molecular Modalities

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.