Liver transplantation has long been a life-saving intervention for individuals with end-stage liver disease. However, its role in treating malignant tumors has evolved significantly over the years. This journal topic explores the dynamic landscape of liver transplantation as a therapeutic option for patients with liver malignancies, shedding light on current perspectives and future directions in the field.
Current perspectives emphasize careful patient selection, locoregional therapies, and tailored immunosuppression. However, future directions are even more promising, with precision medicine, immunotherapy, AI, and innovative organ preservation techniques on the horizon. Genetic profiling of tumors may enable personalized treatment approaches, identifying patients who can benefit the most from transplantation. As immunotherapy is gaining prominence in cancer treatment, we anticipate that combining liver transplantation with immunomodulatory agents could enhance transplant outcomes in this group of patients. AI-driven algorithms for predicting tumor recurrence and patient outcomes are currently being developed. These tools could aid in decision-making and post-transplant surveillance. Innovative organ preservation techniques on the horizon hold the potential to prolong the lifespan of donor livers, effectively mitigating the organ shortage. Furthermore, these advancements may also broaden the scope of transplantation to encompass other medical conditions that are currently less accepted, including certain cancer-related indications. As research and technology continue to advance, liver transplantation's role in the treatment of cancer is likely to expand, offering new hope to patients facing this challenging diagnosis.
Therefore, the main topics that we would like to discuss are, but not limited to:
1. Hepatocellular carcinoma within Milan Criteria
2. Hepatocellular beyond Milan Criteria
3. Downstaging approaches for Hepatocellular carcinoma
4. Peri-hilar Cholangiocarcinoma
5. Intrahepatic Cholangiocarcinoma
6. Hepatic neuro-endocrine metastases
7. Hepatic Colorectal Metastases
8. Mixed Tumors (Hepatocellular/Cholangiocarcinoma)
9. Patient eligibility for oncologic cases
In addition, we will also focus on surgical techniques and innovations such as: Investigating evolving and surgical techniques, including living donor liver transplantation and split-liver transplantation for the treatment of malignant liver tumors. Analyzing the impact of surgical advancements on patient outcomes, graft function, and long-term survival rates.
As guest editors of this collection, we would be thrilled to have your participation as an esteemed expert in the field. Your contribution could take the form of, but not limited to, either a comprehensive review or an original article on the subject matter. Your insights would greatly enrich the content of this special edition of Frontiers in Surgery.
Keywords:
Liver Transplantation, Visceral Surgery, Treatment of Malignant Tumors, Current Perspectives, Future Directions
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Liver transplantation has long been a life-saving intervention for individuals with end-stage liver disease. However, its role in treating malignant tumors has evolved significantly over the years. This journal topic explores the dynamic landscape of liver transplantation as a therapeutic option for patients with liver malignancies, shedding light on current perspectives and future directions in the field.
Current perspectives emphasize careful patient selection, locoregional therapies, and tailored immunosuppression. However, future directions are even more promising, with precision medicine, immunotherapy, AI, and innovative organ preservation techniques on the horizon. Genetic profiling of tumors may enable personalized treatment approaches, identifying patients who can benefit the most from transplantation. As immunotherapy is gaining prominence in cancer treatment, we anticipate that combining liver transplantation with immunomodulatory agents could enhance transplant outcomes in this group of patients. AI-driven algorithms for predicting tumor recurrence and patient outcomes are currently being developed. These tools could aid in decision-making and post-transplant surveillance. Innovative organ preservation techniques on the horizon hold the potential to prolong the lifespan of donor livers, effectively mitigating the organ shortage. Furthermore, these advancements may also broaden the scope of transplantation to encompass other medical conditions that are currently less accepted, including certain cancer-related indications. As research and technology continue to advance, liver transplantation's role in the treatment of cancer is likely to expand, offering new hope to patients facing this challenging diagnosis.
Therefore, the main topics that we would like to discuss are, but not limited to:
1. Hepatocellular carcinoma within Milan Criteria
2. Hepatocellular beyond Milan Criteria
3. Downstaging approaches for Hepatocellular carcinoma
4. Peri-hilar Cholangiocarcinoma
5. Intrahepatic Cholangiocarcinoma
6. Hepatic neuro-endocrine metastases
7. Hepatic Colorectal Metastases
8. Mixed Tumors (Hepatocellular/Cholangiocarcinoma)
9. Patient eligibility for oncologic cases
In addition, we will also focus on surgical techniques and innovations such as: Investigating evolving and surgical techniques, including living donor liver transplantation and split-liver transplantation for the treatment of malignant liver tumors. Analyzing the impact of surgical advancements on patient outcomes, graft function, and long-term survival rates.
As guest editors of this collection, we would be thrilled to have your participation as an esteemed expert in the field. Your contribution could take the form of, but not limited to, either a comprehensive review or an original article on the subject matter. Your insights would greatly enrich the content of this special edition of Frontiers in Surgery.
Keywords:
Liver Transplantation, Visceral Surgery, Treatment of Malignant Tumors, Current Perspectives, Future Directions
Important Note:
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.