About this Research Topic
Molecular mechanisms of glioma remain complex, there are many aspects to consider which influence tumor progression. Long non-coding RNAs (lncRNA) are known to influence the biological processes of tumors such as cell proliferation, migration, invasion and apoptosis. Expression levels of lncRNAs have been studied to become dysregulated in gliomas and this has led lncRNAs to be potential diagnostic biomarkers. There have also been developments in identifying potential blood-based biomarkers to predict the development of glioma in people prior to clinical or radiological signs being presented.
Immunotherapy is a developing field of research in oncology and there are studies focusing on the suppression of glioma cells via specific immune targets as a potential therapeutic approach to improving the treatment of gliomas. Studies have demonstrated T cells in GBM helps suppress anti-tumor immunity and the combined blockade of IL-12 and CTLA-4 acts on CD4 (+) cells which leads to increase in effector T cells and inhibits tumor growth.
The goal of this Research Topic is to generate a discussion of the current research around molecular mechanisms and how it influences the progression of glioma and ultimately, the impact this has on patients, prognosis and survival rate.
Topic of interest include:
-Novel biomarkers that influence the progression of glioma
-Blood-based biomarkers in gliomas
-Immune biomarkers and factors that impact tumor immunity
-T-cells and immune cell infiltrates in gliomas
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: glioma, molecular, immunotherapy, biomarker, gliomagenesis, prognostic biomarkers, metastasis, immunity
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