About this Research Topic
Metabolic diseases, such as diabetes, obesity, and metabolic syndrome, have become major health concerns worldwide. These diseases are characterized by dysregulation of glucose, lipid, and amino acid homeostasis, leading to a variety of complications. Understanding the role of these metabolic pathways and identifying ways to maintain their balance is crucial for developing effective strategies to prevent and treat metabolic diseases. In this article, we will delve into the significance of glucose, lipid, and amino acid homeostasis in metabolic disease and explore recent advances in this field.
Glucose is the primary source of energy for the body. Maintaining glucose homeostasis is essential for normal physiological function. However, dysregulation of glucose metabolism can lead to metabolic diseases such as diabetes mellitus. Recent research has focused on elucidating the molecular mechanisms involved in glucose homeostasis, including insulin signaling, hepatic glucose production, and glucose uptake in peripheral tissues. Advances in understanding these mechanisms have led to the development of novel therapeutic approaches, such as targeting insulin resistance and glucagon-like peptide-1 (GLP-1) receptor activation.
Lipids play a vital role in energy storage, membrane integrity, and signaling. Dysregulation of lipid metabolism is associated with obesity, insulin resistance, and cardiovascular diseases. Recent studies have uncovered the intricate regulatory networks involved in lipid homeostasis, including lipogenesis, lipolysis, and fatty acid oxidation. Furthermore, the identification of key transcriptional regulators, such as peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding proteins (SREBPs), has opened up new avenues for therapeutic intervention. Targeting these regulators using pharmacological agents has shown promising results in preclinical and clinical studies.
Amino acids are not only the building blocks of proteins but also play critical roles in various metabolic pathways. Imbalances in amino acid metabolism have been linked to metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease. Recent research has focused on understanding the interplay between amino acid metabolism and insulin signaling, as well as the impact of amino acid supplementation on metabolic health. Additionally, the gut microbiota has emerged as a key player in amino acid metabolism, highlighting the importance of the gut-brain axis in metabolic disease development and treatment.
In recent years, technological advancements have revolutionized our understanding of metabolic disease and opened up new avenues for intervention. High-throughput omics technologies, such as genomics, transcriptomics, proteomics, and metabolomics, have enabled comprehensive profiling of metabolic pathways and the identification of disease-associated biomarkers. Furthermore, the advent of artificial intelligence and machine learning algorithms has facilitated the analysis of vast amounts of data, allowing for the discovery of novel therapeutic targets and personalized treatment strategies. Additionally, the development of targeted therapies, such as GLP-1 receptor agonists and PPAR modulators, has shown promising results in clinical trials, providing hope for improved management of metabolic diseases.
This special collection aims to collect reviews and research papers on the role of glucose, lipid, and amino acid metabolism in the occurrence and progression of metabolic disease and associated diseases. Within the confines of this collection, an exhaustive exploration of the intricate interplay between metabolic pathways and the trajectory of pathological conditions is undertaken. This encompasses an in-depth investigation into the dynamic interrelationships among diverse factors, such as endocrine hormones and their influence on metabolic regulation, the impact of mitochondrial oxidative stress on metabolic homeostasis, the intricate association between epigenetic modifications and metabolic regulation, the equilibrium between amino acid metabolism and glucose metabolism homeostasis, molecular networks governing hepatic glucose and lipid metabolism, as well as the regulatory mechanisms by which novel hormones modulate glucose, lipid, and amino acid metabolism.
Glucose is the primary source of energy for the body. Maintaining glucose homeostasis is essential for normal physiological function. However, dysregulation of glucose metabolism can lead to metabolic diseases such as diabetes mellitus. Recent research has focused on elucidating the molecular mechanisms involved in glucose homeostasis, including insulin signaling, hepatic glucose production, and glucose uptake in peripheral tissues. Advances in understanding these mechanisms have led to the development of novel therapeutic approaches, such as targeting insulin resistance and glucagon-like peptide-1 (GLP-1) receptor activation.
Lipids play a vital role in energy storage, membrane integrity, and signaling. Dysregulation of lipid metabolism is associated with obesity, insulin resistance, and cardiovascular diseases. Recent studies have uncovered the intricate regulatory networks involved in lipid homeostasis, including lipogenesis, lipolysis, and fatty acid oxidation. Furthermore, the identification of key transcriptional regulators, such as peroxisome proliferator-activated receptors (PPARs) and sterol regulatory element-binding proteins (SREBPs), has opened up new avenues for therapeutic intervention. Targeting these regulators using pharmacological agents has shown promising results in preclinical and clinical studies.
Amino acids are not only the building blocks of proteins but also play critical roles in various metabolic pathways. Imbalances in amino acid metabolism have been linked to metabolic disorders, including insulin resistance and non-alcoholic fatty liver disease. Recent research has focused on understanding the interplay between amino acid metabolism and insulin signaling, as well as the impact of amino acid supplementation on metabolic health. Additionally, the gut microbiota has emerged as a key player in amino acid metabolism, highlighting the importance of the gut-brain axis in metabolic disease development and treatment.
In recent years, technological advancements have revolutionized our understanding of metabolic disease and opened up new avenues for intervention. High-throughput omics technologies, such as genomics, transcriptomics, proteomics, and metabolomics, have enabled comprehensive profiling of metabolic pathways and the identification of disease-associated biomarkers. Furthermore, the advent of artificial intelligence and machine learning algorithms has facilitated the analysis of vast amounts of data, allowing for the discovery of novel therapeutic targets and personalized treatment strategies. Additionally, the development of targeted therapies, such as GLP-1 receptor agonists and PPAR modulators, has shown promising results in clinical trials, providing hope for improved management of metabolic diseases.
This special collection aims to collect reviews and research papers on the role of glucose, lipid, and amino acid metabolism in the occurrence and progression of metabolic disease and associated diseases. Within the confines of this collection, an exhaustive exploration of the intricate interplay between metabolic pathways and the trajectory of pathological conditions is undertaken. This encompasses an in-depth investigation into the dynamic interrelationships among diverse factors, such as endocrine hormones and their influence on metabolic regulation, the impact of mitochondrial oxidative stress on metabolic homeostasis, the intricate association between epigenetic modifications and metabolic regulation, the equilibrium between amino acid metabolism and glucose metabolism homeostasis, molecular networks governing hepatic glucose and lipid metabolism, as well as the regulatory mechanisms by which novel hormones modulate glucose, lipid, and amino acid metabolism.
Keywords: glucose metabolism, lipid metabolism, amino acid metabolism and metabolic diseases
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