Androgen Receptors in Male and Female Reproduction

Androgen receptors play a crucial role in male and female reproduction, influencing various aspects of fertility and reproductive health. In the context of reproductive physiology, androgen receptors manifest within the reproductive tissues of both genders, orchestrating responses to androgens such as testosterone and dihydrotestosterone. Their regulatory functions encompass critical processes like gametogenesis, steroidogenesis and the intricate development of the reproductive tract.

Recent advances have spotlighted three key domains:

1. Female reproduction: androgen receptors intricately shape ovarian folliculogenesis, oocyte maturation and uterine receptivity, thus impacting fertility dynamics and the crucial phase of embryo implantation.

2. Male reproduction: the integral role of androgen receptors is highlighted in the regulation of spermatogenesis, ensuring optimal sperm production and quality to facilitate successful fertilization.

3. Fetal development: emerging insights suggest that androgen receptors significantly contribute to sexual differentiation during embryogenesis, playing a pivotal role in molding gender-specific reproductive characteristics.

This Research Topic welcomes contributions of any type (clinical trial, correction, editorial, general commentary, hypothesis & theory, methods, mini review, opinion, original research, perspective, policy and practice reviews, review, study protocol, systematic review, technology and code) on topics around the role of androgen receptors, including but not limited to:

 Hormone signaling and reproductive functions
 Pathogenesis of Polycystic Ovary Syndrome
 Pathogenesis of Testicular Disorders
 Influence on Assisted Reproductive Technologies
 Influence in Cancer and Reproduction