About this Research Topic
With the development of novel technologies like high-throughput genomics, artificial intelligence simulation, and epigenetic methods, researchers have gained a dynamic map of important protein action in tumor progression across time and space. Therefore, we have recognized that protein targets could be perturbed by manipulating various related aspects and properties, such as protein homeostasis and the status of upstream sequences, leading to corresponding therapeutic outcomes.
The goal of this Research Topic is to provide a forum to advance research on the investigation of proteins that hold significance in tumor therapy, along with their corresponding regulatory methodologies. We hope to amalgamate unique insights and designs in the regulatory approaches employed for tumor-associated proteins, deliberate upon their actions in influencing tumor advancement and modulating immune responses, and authenticate their potential for therapeutic utilization.
We welcome Original Research, Review, Mini Review and Perspective articles on themes including, but not limited to:
(1) Identifying novel protein targets in tumor progression or immune processes and/or revealing their mechanisms;
(2) Developing methods to modulate protein targets within tumor or immune cells, or in the tumor microenvironment, including classical direct modulation approaches (such as target-specific small molecules, peptides, proteins, nucleic acids, and antibodies) and novel modulation approaches (such as protein phase transitions, protein homeostasis perturbations, promotion of protein degradation or antidegradation, or applying extrinsic influences through engineered cells, extracellular vesicles, etc.);
(3) Employing advanced technologies (including methods in bioinformatics, epigenetics, and artificial intelligence) to discover novel and valuable processes related to pivotal proteins in tumor progression or tumor immunity.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Keywords: Protein Targets, Tumor Therapy, Immunomodulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.