About this Research Topic
As the global population ages, the importance of understanding neurological disorders increases exponentially. Two significant threats in this area, neuroviruses and neurocancer, disproportionately affect older demographics. Proteolysis Targeting Chimeras (PROTACs) are groundbreaking molecules that have the potential to redefine how we approach disease treatment. PROTACs are unique molecules designed to target specific proteins for degradation. They function by linking a target protein to a ubiquitin ligase, leading to the protein's tagging and subsequent degradation by the proteasome. This targeted protein degradation offers a precision tool in disease intervention, unlike traditional therapies that merely inhibit proteins. Neurodegenerative disorders like Alzheimer's and Parkinson's disease, which have been linked to viral infections, represent some of the most devastating impacts of neuroviruses on the elderly. These diseases, rooted in protein misfolding and accumulation, underscore the urgency of understanding the interaction of neuroviruses and aging. On the other hand, glioblastoma, a severe form of brain cancer, exemplifies the insidious nature of neurocancers in the elderly. Its aggressive progression and the challenges it poses in diagnosis and treatment emphasize the need for innovative therapeutic interventions.
This research topic aims to explore the intersection of neuroviruses, neurocancer, and the application of PROTACs in the context of aging. By examining the potential of PROTACs to target and degrade proteins associated with neurodegenerative diseases and neurocancers, we seek to uncover new therapeutic pathways. The research will address specific questions such as how PROTACs can be effectively utilized against neuroviruses linked to Alzheimer's and Parkinson's, and their role in combating aggressive neurocancers like glioblastoma. Additionally, the ethical and practical implications of using PROTACs in elderly patients will be critically assessed.
To gather further insights in the complex interplay between neuroviruses, neurocancer, and aging, we welcome articles addressing, but not limited to, the following themes:
- The role of common neuroviruses in exacerbating neurodegenerative diseases in the elderly.
- Mechanisms through which aging influences the progression of neuroviruses and neurocancer.
- The application of PROTACs in targeting proteins associated with Alzheimer's and Parkinson's diseases.
- Innovative strategies for managing glioblastoma and other neurocancers in geriatric populations.
- Ethical considerations and practical challenges in deploying PROTACs for elderly patients.
- Interdisciplinary approaches to enhance collaboration among neurologists, oncologists, geriatricians, and bioethicists.
This research topic aims to explore the intersection of neuroviruses, neurocancer, and the application of PROTACs in the context of aging. By examining the potential of PROTACs to target and degrade proteins associated with neurodegenerative diseases and neurocancers, we seek to uncover new therapeutic pathways. The research will address specific questions such as how PROTACs can be effectively utilized against neuroviruses linked to Alzheimer's and Parkinson's, and their role in combating aggressive neurocancers like glioblastoma. Additionally, the ethical and practical implications of using PROTACs in elderly patients will be critically assessed.
To gather further insights in the complex interplay between neuroviruses, neurocancer, and aging, we welcome articles addressing, but not limited to, the following themes:
- The role of common neuroviruses in exacerbating neurodegenerative diseases in the elderly.
- Mechanisms through which aging influences the progression of neuroviruses and neurocancer.
- The application of PROTACs in targeting proteins associated with Alzheimer's and Parkinson's diseases.
- Innovative strategies for managing glioblastoma and other neurocancers in geriatric populations.
- Ethical considerations and practical challenges in deploying PROTACs for elderly patients.
- Interdisciplinary approaches to enhance collaboration among neurologists, oncologists, geriatricians, and bioethicists.
Keywords: PROTACs, Neurovirus, Cancer, Infections, MD simulation, Infection dynamics, Alzheimer's Disease, Parkinson's Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
