About this Research Topic
Circadian rhythms are changes in the body, brain, and behavior that occur on a 24-hour cycle. Circadian rhythms have an impact on several vital bodily processes, including hormone production, digestion, and eating patterns as well as temperature regulation of the body. Studies showed that there is a relationship between circadian rhythm and obesity, cancer, sleep disorders, mental health disorders, infection, inflammation, cardiovascular problems, type 2 diabetes mellitus, hypertriglyceridemia, and hyperglycemia. Mutations or epigenetic alterations on core circadian clock genes (BMAL1, CLOCK,CRY, PER) can cause alterations in the regulation of the brain, heart, muscle, liver, adipose tissue, pancreas, intestine, and, immune system.
The impact of disturbed circadian rhythms on metabolism is an increasingly concerning aspect of metabolic syndrome. The primary goal of this collection is to explore the epigenetic alterations in the constituents of the circadian clock and their influence on metabolic disorders. These fascinating research areas present an overview of the epigenetic regulation of the circadian clock and the consequences of epigenetic dysregulation in terms of metabolic disorders. The reversible nature of epigenetic alterations makes them a promising target for treatment. Based on this characteristic, this Research Topic will provide a comprehensive explanation of the intricate relationships between epigenetic regulation, circadian rhythm, and metabolism. Additionally, the Research Topic will serve to emphasize recent research that suggests that chronomedicine, which will become more significant in the next years, may offer new opportunities for therapeutic advancement.
The goal of this Research Topic is to compile the most recent discoveries and developments in the fields of chronobiology and epigenetics. Original research, systematic reviews, mini-reviews, hypotheses and theories, methodological contributions, letters to the editor, comments, and opinions are all welcome. The topic is broad and is meant to include, but not be limited to:
• Epigenetic alterations in obesity
• Epigenetic alterations in sleep disorders
• Epigenetic alterations in type 2 diabetes mellitus
• Epigenetic alterations in hyperglycemia
• Epigenetic alterations in metabolic dysfunction
• Epigenetic alterations and eating habits in metabolic disorders
The impact of disturbed circadian rhythms on metabolism is an increasingly concerning aspect of metabolic syndrome. The primary goal of this collection is to explore the epigenetic alterations in the constituents of the circadian clock and their influence on metabolic disorders. These fascinating research areas present an overview of the epigenetic regulation of the circadian clock and the consequences of epigenetic dysregulation in terms of metabolic disorders. The reversible nature of epigenetic alterations makes them a promising target for treatment. Based on this characteristic, this Research Topic will provide a comprehensive explanation of the intricate relationships between epigenetic regulation, circadian rhythm, and metabolism. Additionally, the Research Topic will serve to emphasize recent research that suggests that chronomedicine, which will become more significant in the next years, may offer new opportunities for therapeutic advancement.
The goal of this Research Topic is to compile the most recent discoveries and developments in the fields of chronobiology and epigenetics. Original research, systematic reviews, mini-reviews, hypotheses and theories, methodological contributions, letters to the editor, comments, and opinions are all welcome. The topic is broad and is meant to include, but not be limited to:
• Epigenetic alterations in obesity
• Epigenetic alterations in sleep disorders
• Epigenetic alterations in type 2 diabetes mellitus
• Epigenetic alterations in hyperglycemia
• Epigenetic alterations in metabolic dysfunction
• Epigenetic alterations and eating habits in metabolic disorders
Keywords: Circadian Rythm, Metabolism, Hormones, Sleep, Diabetes, Hyperglycemia, Regulations
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