About this Research Topic

Background

Soft tissues, which encompass all organs of the body, such as the brain, muscles, and tendons, play a crucial role in maintaining the normal function in the human body. Understanding the biomechanics and mechanobiology of these tissues by integrating computational and experimental approaches is essential for advancing the clinical treatments, medical device development and overall healthcare. This topic outlines multidisciplinary research on understanding soft tissues’ biomechanics and mechanobiology under various physiological and pathological conditions.

The proposed topic aims to combine experimental and computational methods to gain insights into the complex mechanical behaviors of soft tissues. To achieve this goal, this Research Topic will focus on some specific objectives like developing novel computational models to elucidate soft tissue behavior and quantifying the effects of diseases, characterizing soft tissue properties by advancing experimental techniques, such as tissue testing, imaging and microscale analysis. This will help in characterizing the mechanical properties and structural behavior of various soft tissues under both physiological and pathological conditions. We welcome the studies that investigates mechanobiological processes such as tissue remodeling, adaption, and injury, by integrating computational models with experimental data to gain insights into mechanical behavior. The studies that apply the findings from this research to improve clinical applications, such as subject-specific treatment, development of medical devices and regenerative medicine.

This topic will also cover the interdisciplinary research by integrating biomechanics, biology, engineering, clinical studies, and imaging techniques.
• Computational modeling development
• Machine learning applications
• Experimental characterization
• Imaging processing techniques
• Mechanobiological processes
• Disease mechanisms
• Application in clinical treatments and medical devices

Keywords: Computational modeling, experimental test, material behavior, constitutive relationship, physiological and pathological mechanisms

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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