About this Research Topic
Cardiac dysfunction, commonly known as heart failure, is when the heart pumping ability is reduced. It is characterized by the inability of systemic perfusion to meet the body's metabolic demands and unable to pump the required amount of blood throughout the body. All cardiovascular diseases (CVDs) progress to heart failure (HF) if not effectively treated and affects almost 1–2% of the world’s population. CVDs mainly include myocardial infarction (608446), atherosclerosis (108725), myocardial hypertrophy (192600), diabetic cardiomyopathy (115200) etc. Current treatment for heart dysfunction depends upon the healthy lifestyle habits, medications, surgery or other medical procedures like stents, bypass surgery.
The basic biological interest is to understand the mechanisms of progression of cardiovascular dysfunction. Currently, there is an urgent need to develop a novel, and efficient approach for the treatment of CVDs. Ferroptosis is iron-dependent programmed cell death caused by excessive accumulation of iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. Recent studies have confirmed that ferroptosis is associated with the development of CVDs and may be a potential therapeutic medicine target for CVDs.
This Research topic will mainly focus on the development of novel therapeutics, diagnoses, translational studies, and advancements in cardiovascular disease. Its core interest is to identify a basic molecular and cellular mechanism for discovering novel targets in cardiovascular research. The studies should focus on the mechanisms for progression and occurrence of cardiovascular disease and ideas for the development of novel inhibitors to resolve cardiovascular problems.
We welcome original research, systematic reviews, mini reviews, perspectives, clinical trials, case reports, and data reports. Topic of interests includes, but are not limited to the following:
• Mechanism of cardiovascular disease
• Novel therapeutics, diagnoses, and advancements in cardiovascular disease
• Discovering novel targets in cardiovascular research
• Ferroptosis role in cardiovascular disease and cardiac dysfunction
The basic biological interest is to understand the mechanisms of progression of cardiovascular dysfunction. Currently, there is an urgent need to develop a novel, and efficient approach for the treatment of CVDs. Ferroptosis is iron-dependent programmed cell death caused by excessive accumulation of iron-dependent lipid reactive oxygen species and the imbalance of redox homeostasis. Recent studies have confirmed that ferroptosis is associated with the development of CVDs and may be a potential therapeutic medicine target for CVDs.
This Research topic will mainly focus on the development of novel therapeutics, diagnoses, translational studies, and advancements in cardiovascular disease. Its core interest is to identify a basic molecular and cellular mechanism for discovering novel targets in cardiovascular research. The studies should focus on the mechanisms for progression and occurrence of cardiovascular disease and ideas for the development of novel inhibitors to resolve cardiovascular problems.
We welcome original research, systematic reviews, mini reviews, perspectives, clinical trials, case reports, and data reports. Topic of interests includes, but are not limited to the following:
• Mechanism of cardiovascular disease
• Novel therapeutics, diagnoses, and advancements in cardiovascular disease
• Discovering novel targets in cardiovascular research
• Ferroptosis role in cardiovascular disease and cardiac dysfunction
Keywords: Heart dysfunction, Ferroptosis, Cardiovascular diseases, Therapeutic target, Heart failure, iron-dependent programmed cell death
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
