About this Research Topic

Background

This exciting Research Topic is the second volume of the Research Topic "Diabetic Kidney Disease: Routes to drug development, pharmacology and underlying molecular mechanisms." Please see the first volume here.

Diabetic kidney disease is a leading cause of end-stage renal disease which affects one third of the total diabetic patients worldwide. Diabetic kidney disease is also one of the significant long-term complications in terms of morbidity and mortality for individuals with diabetes. A serious knowledge gap exists between biology and drug development which contributes to the suboptimal treatment options against diabetic nephropathy. An increased understanding of diabetic kidney disease is urgently needed for the development of novel therapeutics that can be targeted to the early stages of these diseases. Currently approved therapeutic regimens can slow down, but not prevent the progression of end-stage kidney disease, and are associated with side effects and intolerance. Thus, there is a clear need for new therapeutic strategies to improve renal function in diabetic patients.

In this Research Topic, we invite Original Research as well as Review articles to provide a deeper insight into the new pathophysiologic pathways and mechanisms that can be used in targeting diverse phenotypes of diabetic kidney disease. We invite researchers in this field to address the discussion on the mechanistic pathways that are regulators of renal fibrosis.

Understanding of critical pathways will guide the future therapies against diabetic kidney disease. We welcome manuscripts including, but not limited to, the following themes:

o Therapeutic regimens for the management of diabetes kidney disease

o Identification of new biological pathways

o Cell and tissue-specific mechanisms

o Regulatory microRNAs in renal fibrosis

o Mechanisms of diabetic kidney disease

o Clinical data sets

o Antisense nucleotides

Keywords: Diabetes, Diabetic kidney, end-stage renal disease, therapeutic approaches, management

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