About this Research Topic
Cardiovascular Diseases (CVDs) and neuropsychiatric symptoms significantly impact on human health. CVDs encompass an array of heart and circulatory system disorders, including coronary heart disease, valvular heart disease, congenital heart disease, cardiomyopathy, diseases of the great vessels, and more. Regarding neuropsychiatric symptoms, here it refers specifically to intellectual impairment and cognitive impairment.
Despite the distinct anatomy and physiology of the heart and brain, they share a convergence of genetic factors and molecular pathways. In fact, congenital heart anomalies have been linked to heightened susceptibility to cognitive dysfunction. Intriguingly, whole-exome sequencing has unveiled significant genetic overlap between congenital heart disease and cognitive dysfunction-associated gene variants. Instances like Williams syndrome and Noonan syndrome spotlight the co-occurrence of cardiac malformations and intellectual impairment. In patients with heart failure and cognitive decline, notable cerebral changes are frequently observed, including brain atrophy, heightened white matter, diminished gray matter, and clinically silent cerebral infarctions. Furthermore, individuals grappling with intellectual disabilities exhibit an elevated vulnerability to cardio-cerebrovascular diseases such as coronary heart disease, strokes, cardiac failure, and deep vein thrombosis. This vulnerability escalates with the severity of intellectual impairment.
To encapsulate, CVDs and intellectual and/or cognitive impairment share intricate connections, and a comprehensive exploration into their underlying pathogenic mechanisms offers profound potential for unraveling the enigmatic origins of these ailments.
The primary objective of this research is to delve into the intricate genetic and epigenetic pathways that underlie CVDs and intellectual and/or cognitive impairment. This study also seeks to uncover the nuanced clinical interconnections between CVDs and intellectual and/or cognitive impairment. We extend a warm invitation to enthusiastic researchers to contribute their insights through the submission of review articles and original studies. These submissions can encompass a broad spectrum, including investigations conducted on cellular models, animal models, and human samples. By fostering such research endeavors, we aspire to push the boundaries of knowledge concerning the genetic and epigenetic origins of CVDs and intellectual and/or cognitive impairment, thereby making strides in our understanding of their etiology.
• Interactions between genetic and environmental factors in CVDs and intellectual and/or cognitive impairment.
• Identification of novel causative genes and variants for underlying CVDs and intellectual and/or cognitive impairment.
• Molecular mechanisms of driving CVDs and intellectual and/or cognitive impairment.
• Illuminating insights through clinical observational study of CVDs and intellectual and/or cognitive impairment.
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Despite the distinct anatomy and physiology of the heart and brain, they share a convergence of genetic factors and molecular pathways. In fact, congenital heart anomalies have been linked to heightened susceptibility to cognitive dysfunction. Intriguingly, whole-exome sequencing has unveiled significant genetic overlap between congenital heart disease and cognitive dysfunction-associated gene variants. Instances like Williams syndrome and Noonan syndrome spotlight the co-occurrence of cardiac malformations and intellectual impairment. In patients with heart failure and cognitive decline, notable cerebral changes are frequently observed, including brain atrophy, heightened white matter, diminished gray matter, and clinically silent cerebral infarctions. Furthermore, individuals grappling with intellectual disabilities exhibit an elevated vulnerability to cardio-cerebrovascular diseases such as coronary heart disease, strokes, cardiac failure, and deep vein thrombosis. This vulnerability escalates with the severity of intellectual impairment.
To encapsulate, CVDs and intellectual and/or cognitive impairment share intricate connections, and a comprehensive exploration into their underlying pathogenic mechanisms offers profound potential for unraveling the enigmatic origins of these ailments.
The primary objective of this research is to delve into the intricate genetic and epigenetic pathways that underlie CVDs and intellectual and/or cognitive impairment. This study also seeks to uncover the nuanced clinical interconnections between CVDs and intellectual and/or cognitive impairment. We extend a warm invitation to enthusiastic researchers to contribute their insights through the submission of review articles and original studies. These submissions can encompass a broad spectrum, including investigations conducted on cellular models, animal models, and human samples. By fostering such research endeavors, we aspire to push the boundaries of knowledge concerning the genetic and epigenetic origins of CVDs and intellectual and/or cognitive impairment, thereby making strides in our understanding of their etiology.
• Interactions between genetic and environmental factors in CVDs and intellectual and/or cognitive impairment.
• Identification of novel causative genes and variants for underlying CVDs and intellectual and/or cognitive impairment.
• Molecular mechanisms of driving CVDs and intellectual and/or cognitive impairment.
• Illuminating insights through clinical observational study of CVDs and intellectual and/or cognitive impairment.
All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Keywords: Cardiovascular diseases, Intellectual impairment, Cognitive impairment, Genetic abnormalities, Pathogenic mechanism
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
