About this Research Topic
Older adults often encounter higher morbidity due to factors such as frailty, geriatric conditions, and multimorbidity. Essentially, the immune system of older adults undergoes dramatic aging-related changes, which will continuously progress to immunosenescence. The aging immune system loses the ability to protect against infections, cancer, and metabolic disorders, and fails to support appropriate wound healing. Traditional treatments may not be appropriate for older patients, particularly those with multimorbidity and functional dependency. The lack of investigation and characterization of older patients suffering from immunosenescence results in challenges in the health management of older patients.
With advances in precision medicine, the assessment and prediction based on omics data provide important guidance for the treatment of age-related diseases. Also, cell culture and animal models that reflect functional status, cognition, nutritional status, multimorbidity, and polypharmacy are critical for further validation of targets and drugs. These biotechnologies and information technologies are highly encouraged in this Research Topic to have better knowledge and understanding of immunosenescence-related and inflammaging-related diseases. We are also interested in identifying novel immune-related pathways and interactions that are dysregulated in age-related diseases and exploring their functional significance in the context of immunosenescence and inflammaging.
We welcome the submission of Original Research papers, Methods papers, and Review articles on experimental and computational results in the fields of aging and immunosenescence, including issues regarding genetics, omics, clinical outcomes prediction, and the development of immunosenescence-specific and inflammaging-specific algorithms in cancer, neurological disease, metabolic disease, etc. Subtopics of interest include but are not limited to:
• Molecular analysis and functional studies in age-related diseases, which depict the process of immunosenescence and inflammaging
• Research focused on characterizing the nature of immunosenescence-related and inflammaging-related diseases and the correlation between the clinical picture and the disease genotype
• Discovery of new subsets of immune-related cells in immunosenescence-related and inflammaging-related diseases
• Development of data-analytical and experimental methods to enable understanding of inflammatory mechanisms in age-related diseases
• Application of clinical and omics data in screening, diagnosis, prognosis, treatment, and monitoring of geriatric patients
Please NOTE: External validation or comprehensive evaluation of the identified markers is required in this Research Topic.
Keywords: Immunosenescence, Inflammaging, Geriatric Medicine, Multimorbidity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.