About this Research Topic
This research topic aims to assemble original research articles, reviews, and perspectives that highlight the latest advances in the study of developmental and adult haematopoiesis. The primary goal is to elucidate the molecular mechanisms and biochemical cues that promote haematopoietic stem and progenitor cell generation, self-renewal, and differentiation. Additionally, the research will explore novel strategies and technologies to study the haematopoietic niche, including spatial multi-omics approaches and large-scale drug screenings. By addressing these questions, the research aims to develop more effective treatments for haematological diseases and improve the reliable expansion of donor HSCs in vitro or their production de novo from human pluripotent stem cells.
To gather further insights into the plasticity of the haematopoietic niche from embryonic development to aging and disease, we welcome articles addressing, but not limited to, the following themes:
- Haematopoietic niches during embryonic development, from the yolk sac and dorsal aorta to the foetal liver and bone marrow.
- The bone marrow microenvironment and secondary haematopoietic sites in adult health, aging, and disease.
- Molecular mechanisms and biochemical cues promoting haematopoietic stem and progenitor cell generation, self-renewal, and differentiation.
- Novel strategies and technologies to study the haematopoietic niche, including spatial multi-omics approaches and large-scale drug screenings.
- The diversity of model systems to study haematopoiesis, from animal embryos to human pluripotent stem cells.
Keywords: haematopoiesis, haematopoietic niche, haematopoietic stem cells, adult haematopoiesis, haematopoietic
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.