About this Research Topic

Background

Per- and Polyfluoroalkyl substances (PFAS), are a diverse group of synthetic organofluorine
chemicals that are valued for their amphiphilicity, heat resistance, and chemical stability.
Production and use of PFAS in commercial and industrial applications has led to
contamination of both the natural and built environments at a global scale. It is estimated
that the number of PFAS and PFAS-related chemicals has surpassed 9,000, and there are
likely many more that have yet to be identified. Because PFAS are persistent, ubiquitous,
and diverse in both structure and origin there are serious concerns regarding the long-term
impacts of PFAS exposure on human, animal, and ecosystem health.

This research topic aims to deliver the latest scientific developments and findings on the
toxicology of PFAS exposures with specific focus on real world mixtures and emerging
PFAS. Innovative and cutting-edge research that explores PFAS toxicokinetic and toxicity
profiles by alternative testing methodologies (i.e., in vitro toxicity testing, omics, in silico
methods, in vitro to in vivo extrapolation methods) and population studies (e.g., epidemiology
and wildlife studies) will be highlighted. Emphasis will be placed on understanding the
effects of PFAS exposure and their contribution to the development of chronic immune,
neurodevelopmental, and endocrine phenotypes.

Researchers and experts from diverse disciplines including toxicology, environmental
science, chemistry, epidemiology, and public health are encouraged to contribute their
insights, innovative methodologies, and cutting-edge research to broaden our understanding
of the toxicology of PFAS. This collective effort will pave the way for informed decision-
making, providing a foundation for protective measures, and ultimately safeguarding
ecosystems and human well-being in the face of PFAS contamination.

Keywords: Per- and polyfluoroalkyl substances, toxicology, environmental impact, human health risks, exposure, mechanism of toxicity, endocrine disruption, immunotoxicity, developmental abnormalities, chronic diseases, One Health, PFAS

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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