About this Research Topic
The human gut microbiota is a complex and dynamic ecosystem that plays a crucial role in human health. It is involved in various physiological functions, including digestion, vitamin synthesis, and immune system development. Recent research has demonstrated a strong correlation between gut microbiota and metabolic diseases such as obesity, diabetes, and cardiovascular diseases. Dysbiosis, characterized by alterations in the composition and function of gut microbiota, has been associated with the onset and progression of these metabolic disorders. Meanwhile, recent research findings have shown that probiotics and prebiotics have a significant regulatory effect on intestinal disorders, thereby alleviating symptoms of metabolic diseases. Probiotics and prebiotics show promise as pharmaceutical interventions for the prevention and treatment of metabolic disorders. The underlying mechanisms behind these associations are not fully elucidated but are believed to involve inflammation, increased intestinal permeability, and changes in energy metabolism. This field of study is rapidly advancing with significant potential for the development of innovative therapeutic strategies targeting metabolic diseases.
One research direction focuses on understanding how the diversity and composition of gut microbiota influence the development and progression of metabolic diseases such as obesity, diabetes, and metabolic syndrome. Recent research suggests that probiotics, beneficial microorganisms that confer health benefits to the host, can play a pivotal role in treating metabolic diseases. The underlying mechanisms through which probiotics exert their effects remain largely unexplored.
Another direction focuses on investigating the effects and potential pharmacological mechanisms of probiotics and prebiotics in treating metabolic diseases. Recent studies have shown that supplementing with probiotics and prebiotics can have a significant impact on the gut microbiota. This, in turn, can affect host metabolism by regulating energy balance and inflammatory responses. Moreover, they can affect the gut barrier function, leading to increased permeability and endotoxemia, which may contribute to the development of metabolic diseases. More comprehensive and in-depth studies are needed to fully understand the complex interactions between probiotics (or prebiotics), gut microbiota, and host metabolism.
We are particularly interested in understanding how the diversity and composition of gut microbiota influence the development and progression of metabolic diseases such as obesity, diabetes, and metabolic syndrome.
Specific themes we would like contributors to address include:
The potential therapeutic strategies targeting gut microbiota for the prevention and treatment of metabolic diseases.
The interaction between gut microbiota and the host's immune system in the context of metabolic diseases.
The influence of gut microbiota on drug metabolism and treatment efficacy for metabolic diseases.
The use of probiotics, prebiotics, and fecal microbiota transplantation(FMT) in managing metabolic diseases.
We welcome different types of manuscripts including original research articles, review articles, method articles, and clinical trials. We are particularly interested in studies that use innovative methodologies to investigate the complex interactions between gut microbiota and metabolic health.
One research direction focuses on understanding how the diversity and composition of gut microbiota influence the development and progression of metabolic diseases such as obesity, diabetes, and metabolic syndrome. Recent research suggests that probiotics, beneficial microorganisms that confer health benefits to the host, can play a pivotal role in treating metabolic diseases. The underlying mechanisms through which probiotics exert their effects remain largely unexplored.
Another direction focuses on investigating the effects and potential pharmacological mechanisms of probiotics and prebiotics in treating metabolic diseases. Recent studies have shown that supplementing with probiotics and prebiotics can have a significant impact on the gut microbiota. This, in turn, can affect host metabolism by regulating energy balance and inflammatory responses. Moreover, they can affect the gut barrier function, leading to increased permeability and endotoxemia, which may contribute to the development of metabolic diseases. More comprehensive and in-depth studies are needed to fully understand the complex interactions between probiotics (or prebiotics), gut microbiota, and host metabolism.
We are particularly interested in understanding how the diversity and composition of gut microbiota influence the development and progression of metabolic diseases such as obesity, diabetes, and metabolic syndrome.
Specific themes we would like contributors to address include:
The potential therapeutic strategies targeting gut microbiota for the prevention and treatment of metabolic diseases.
The interaction between gut microbiota and the host's immune system in the context of metabolic diseases.
The influence of gut microbiota on drug metabolism and treatment efficacy for metabolic diseases.
The use of probiotics, prebiotics, and fecal microbiota transplantation(FMT) in managing metabolic diseases.
We welcome different types of manuscripts including original research articles, review articles, method articles, and clinical trials. We are particularly interested in studies that use innovative methodologies to investigate the complex interactions between gut microbiota and metabolic health.
Keywords: gut microbiota; metabolic diseases; probiotics; prebiotics; mechanisms
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
