About this Research Topic

Background

The field of organ preservation strategies in cancer management has seen significant advancements, offering patients improved quality of life without compromising survival outcomes. However, there are ongoing debates and challenges in conducting randomized controlled trials comparing organ preservation to standard surgical management. The buy-in from multiple oncologic specialties and patient participation remains a hurdle. Despite these challenges, recent studies have shown promising results in the use of organ preservation strategies across various disease sites, particularly with the use of radiation therapy. However, there is a need for a better investigation and a multidisciplinary perspective on adjusting treatment intensity while balancing cancer control, organ function, and quality of life.

The main aim of this research topic is to explore the controversies and emerging evidence in novel organ-preservation strategies for various disease sites, with a particular focus on radiation therapy. The goal is to collect review articles that provide a comprehensive overview of the current state of organ preservation strategies, including the latest technological advancements, patient preferences, risks associated with organ preservation, and available salvage options. The research also aims to evaluate key studies or trials comparing organ preservation to standard surgical management and identify the barriers and challenges in adopting these strategies.

The scope of this research topic is defined by its focus on organ preservation strategies in cancer management, particularly in the context of radiation therapy. We welcome articles addressing, but not limited to, the following themes:
● Standard surgical techniques for cancer treatment in specific disease sites.
● Technological advancements and developments in surgery, radiation oncology, and medical oncology that facilitate organ preservation.
● Patient preferences and the impact of organ preservation on patient-reported outcomes.
● Risks associated with organ preservation and available salvage options.
● Evaluation of key studies or trials comparing organ preservation to standard surgical management.
● Barriers and challenges in adopting organ preservation strategies.
● Identification of necessary technologies and scientific advancements for wider acceptance and implementation of organ preservation.
● Identification of clinical trials needed to further establish the effectiveness of organ preservation strategies.

Please note: Manuscripts consisting solely of bioinformatics, computational analysis, or predictions of public databases which are not accompanied by validation (independent clinical or patient cohort, or biological validation in vitro or in vivo, which are not based on public databases) are not suitable for publication in this journal.

Article types and fees

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• ... View all formats

Articles that are accepted for publication by our external editors following rigorous peer review incur a publishing fee charged to Authors, institutions, or funders.

Article types

This Research Topic accepts the following article types, unless otherwise specified in the Research Topic description:

• Brief Research Report
• Case Report
• Clinical Trial
• Editorial
• General Commentary
• Hypothesis and Theory
• Methods
• Mini Review
• Opinion
• Original Research
• Perspective
• Review
• Systematic Review
• Technology and Code

Keywords: organ preservation, cancer therapies, review, radiotherapy, surgical management

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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