About this Research Topic
The neuroendocrine system consists of multiple organs including the hypothalamus, pituitary gland, adrenal gland, pineal gland, and thyroid gland. They work together to regulate hormone release and maintain homeostasis in the body. Dysregulation of the neuroendorine system will cause maladaptation to the stress stimulation and is commonly observed in individuals with depression.
The central clock sitting in the suprachiasmatic nucleus of the hypothalamus (SCN) synchronizes the intrinsic circadian rhythm with the exterior circadian cues and maintains the temporal-dependent physiological function. Circadian disruption has been associated with the development of depression.
It is noteworthy that many hormones, such as adrenocorticotropic hormone, cortisol, melatonin, growth hormone, and thyroid hormones, are expressed or released with circadian patterns. Disrupted diurnal variation of hormones is commonly observed in individuals with depression.
This project aims to enhance our knowledge of the neuroendocrine and circadian factors involved in depression, ultimately contributing to the development of innovative therapeutic strategies for this debilitating disorder.
While significant progress has been made in understanding the connections between neuroendocrine factors, circadian disruption, and depression, several challenges and issues still require further research. For instance, while dysregulation of HPA axis activity and hormone release has been associated with depression, the exact mechanisms and their contributions to the development and progression of depression need to be explored in more depth from the circuits and transcription level. The interplay of genetic and environmental factors in mood regulation, as well as the variations in symptoms and responses to treatment among individuals with depression, warrant further investigation.
Moreover, depression often co-occurs with other psychiatric and medical conditions. The roles of the neuroendocrine and circadian systems in these comorbidity processes also require further investigation. Future research in these areas will contribute to a more comprehensive understanding of the complex interactions between neuroendocrine factors, circadian rhythms, and depression, ultimately leading to improved treatment and management strategies for depression and related conditions.
The goal of this specific collection is to provide new insights in this field and help promote new strategies for treatment, based on a deeper understanding of the underlying mechanisms that contribute to depression and its associated conditions.
The scope of this specific collection includes, but is not limited to:
1. Studies investigating the role of circadian systems in the onset and progression of depression.
2. Research exploring the interaction between the neuroendocrine system and mood regulation, with a focus on hormones that exhibit circadian-pattern expressions and their role in mood regulation.
3. Investigations involving the influence of genetic and environmental factors on the endocrine and circadian systems and their effects on the development of depression.
4. Studies delving into the neurobiological mechanisms underlying the association between neuroendocrine factors, circadian rhythms, and depression, with a particular emphasis on molecular and cellular pathways.
5. Clinical research examining the relationships between neuroendocrine abnormalities, circadian disturbances, and specific symptoms of depression, such as anhedonia, and cognitive impairments.
6. Studies exploring novel therapeutic approaches that target the neuroendocrine and circadian systems to improve the management and treatment of depression and related conditions.
The central clock sitting in the suprachiasmatic nucleus of the hypothalamus (SCN) synchronizes the intrinsic circadian rhythm with the exterior circadian cues and maintains the temporal-dependent physiological function. Circadian disruption has been associated with the development of depression.
It is noteworthy that many hormones, such as adrenocorticotropic hormone, cortisol, melatonin, growth hormone, and thyroid hormones, are expressed or released with circadian patterns. Disrupted diurnal variation of hormones is commonly observed in individuals with depression.
This project aims to enhance our knowledge of the neuroendocrine and circadian factors involved in depression, ultimately contributing to the development of innovative therapeutic strategies for this debilitating disorder.
While significant progress has been made in understanding the connections between neuroendocrine factors, circadian disruption, and depression, several challenges and issues still require further research. For instance, while dysregulation of HPA axis activity and hormone release has been associated with depression, the exact mechanisms and their contributions to the development and progression of depression need to be explored in more depth from the circuits and transcription level. The interplay of genetic and environmental factors in mood regulation, as well as the variations in symptoms and responses to treatment among individuals with depression, warrant further investigation.
Moreover, depression often co-occurs with other psychiatric and medical conditions. The roles of the neuroendocrine and circadian systems in these comorbidity processes also require further investigation. Future research in these areas will contribute to a more comprehensive understanding of the complex interactions between neuroendocrine factors, circadian rhythms, and depression, ultimately leading to improved treatment and management strategies for depression and related conditions.
The goal of this specific collection is to provide new insights in this field and help promote new strategies for treatment, based on a deeper understanding of the underlying mechanisms that contribute to depression and its associated conditions.
The scope of this specific collection includes, but is not limited to:
1. Studies investigating the role of circadian systems in the onset and progression of depression.
2. Research exploring the interaction between the neuroendocrine system and mood regulation, with a focus on hormones that exhibit circadian-pattern expressions and their role in mood regulation.
3. Investigations involving the influence of genetic and environmental factors on the endocrine and circadian systems and their effects on the development of depression.
4. Studies delving into the neurobiological mechanisms underlying the association between neuroendocrine factors, circadian rhythms, and depression, with a particular emphasis on molecular and cellular pathways.
5. Clinical research examining the relationships between neuroendocrine abnormalities, circadian disturbances, and specific symptoms of depression, such as anhedonia, and cognitive impairments.
6. Studies exploring novel therapeutic approaches that target the neuroendocrine and circadian systems to improve the management and treatment of depression and related conditions.
Keywords: Circadian Rhythm, Hypothalamus, Chronotherapy, Neuropeptide, Neurotransmitter, Depression
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