About this Research Topic
The complex landscape of tumor biology has recently brought to the forefront the intricate relationship between cellular metabolism and the mechanisms of cell death. As cells undergo metabolic shifts, notably in tumor settings, they exhibit distinct patterns of survival, proliferation, and death. These metabolic pathways and their resultant forms of cell death significantly influence the tumor immune microenvironment, a critical determinant of immunotherapy outcomes. Recent advancements in immunotherapy have spotlighted the importance of understanding this microenvironment, as it serves as both a target and a mediator of therapeutic interventions. Yet, the nuances of how cellular metabolism and associated cell death modulate this environment remain only partially unveiled. A holistic grasp of their interplay is crucial to comprehend tumor progression and to design more effective immunotherapeutic strategies.
The primary objective of this Research Topic is to elucidate the intricate connections between cellular metabolism, its related cell death mechanisms, and their collective influence on the tumor immune microenvironment in the context of immunotherapy. By doing so, we aim to provide insights that could guide the development of next-generation immunotherapeutic strategies with enhanced efficacy against various tumor types.
We cordially invite authors to submit both Original Research articles and comprehensive Review articles that delve into the interplay between cellular metabolism, associated cell death mechanisms, and the tumor immune microenvironment in the realm of immunotherapy. Potential topics of interest encompass, but are not confined to:
1. Mechanistic insights into the interaction of cellular metabolism and associated cell death pathways within the tumor milieu.
2. Influence of diverse metabolism-related cell death modes on the tumor immune microenvironment and its consequent impact on immunotherapy outcomes.
3. Assessment of how metabolism-related cell death mechanisms in the tumor microenvironment correlate with immunotherapeutic responses.
4. Strategies to harness specific metabolism-related cell death pathways to bolster antitumor immune reactions.
5. Exploration of metabolic interventions that might reshape metabolism-related cell death patterns, thereby modulating the immune microenvironment.
6. Recent advancements in tools or methods that enhance our understanding of metabolic shifts and related cell death within the tumor context.
7. Any other pertinent topics related to the intricate relationship between cellular metabolism, metabolism-related cell death, and their implications for the tumor immune microenvironment and immunotherapy.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
The primary objective of this Research Topic is to elucidate the intricate connections between cellular metabolism, its related cell death mechanisms, and their collective influence on the tumor immune microenvironment in the context of immunotherapy. By doing so, we aim to provide insights that could guide the development of next-generation immunotherapeutic strategies with enhanced efficacy against various tumor types.
We cordially invite authors to submit both Original Research articles and comprehensive Review articles that delve into the interplay between cellular metabolism, associated cell death mechanisms, and the tumor immune microenvironment in the realm of immunotherapy. Potential topics of interest encompass, but are not confined to:
1. Mechanistic insights into the interaction of cellular metabolism and associated cell death pathways within the tumor milieu.
2. Influence of diverse metabolism-related cell death modes on the tumor immune microenvironment and its consequent impact on immunotherapy outcomes.
3. Assessment of how metabolism-related cell death mechanisms in the tumor microenvironment correlate with immunotherapeutic responses.
4. Strategies to harness specific metabolism-related cell death pathways to bolster antitumor immune reactions.
5. Exploration of metabolic interventions that might reshape metabolism-related cell death patterns, thereby modulating the immune microenvironment.
6. Recent advancements in tools or methods that enhance our understanding of metabolic shifts and related cell death within the tumor context.
7. Any other pertinent topics related to the intricate relationship between cellular metabolism, metabolism-related cell death, and their implications for the tumor immune microenvironment and immunotherapy.
Please NOTE: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of the scope for this section and will not be accepted as part of this Research Topic.
Keywords: Cellular Metabolism, Cell Death, Tumor Immune Microenvironment, Immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
