About this Research Topic
Percutaneous interventions are the established treatment modality for occlusive vascular disease. In some patients, however, the excessive reparative response of the vessel wall to therapeutic angioplasty results in restenosis, the most common cause of non-surgical revascularization failure. Modeling restenosis in laboratory animals has paralleled clinical research for the past 40 years since balloon and, later, stent interventions were widely introduced in cardiological practice.
Major breakthroughs in the field, such as drug-eluting stents, were preceded by thorough investigations in preclinical animal models.
This Research Topic will present a current landscape of preclinical animal models of restenosis across different species and intervention types. Submitted manuscripts should analyse advantages of the individual model(s) in investigating specific elements of restenosis pathogenesis and its response to local and systemic treatments. Additionally, this Research Topic will address recent and novel developments in the field and discuss how the advent of genetically modified animals and risk factor modulation strategies improves the predictive power of the restenosis model(s). Papers published in this collection will provide a roadmap to streamline translational research for restenosis prevention and treatment through advancing animal testing of anti-restenotic strategies.
The range of percutaneous and surgical techniques, based on balloon and wire injury, stenting, endarterectomy, vascular grafts, and creation of anastomoses, will be considered for inclusion in this Research Topic. While technical papers describing the author’s experience and the "know-how" details in vascular interventions are of primary interest to the Topic Editors, contributions focusing on mechanistic and therapeutic results obtained using diverse models of vascular injury are welcome. Based on their wide use in research, the rodent, rabbit, and pig models including use of genetically modified animals will be primarily presented in the collection. However, the Topic Editors encourage the submission of experimental studies in any vertebrate model of vascular injury.
Articles formatted as Original Research, Method, Review, and Mini-review will be considered for publication in this Research Topic.
Major breakthroughs in the field, such as drug-eluting stents, were preceded by thorough investigations in preclinical animal models.
This Research Topic will present a current landscape of preclinical animal models of restenosis across different species and intervention types. Submitted manuscripts should analyse advantages of the individual model(s) in investigating specific elements of restenosis pathogenesis and its response to local and systemic treatments. Additionally, this Research Topic will address recent and novel developments in the field and discuss how the advent of genetically modified animals and risk factor modulation strategies improves the predictive power of the restenosis model(s). Papers published in this collection will provide a roadmap to streamline translational research for restenosis prevention and treatment through advancing animal testing of anti-restenotic strategies.
The range of percutaneous and surgical techniques, based on balloon and wire injury, stenting, endarterectomy, vascular grafts, and creation of anastomoses, will be considered for inclusion in this Research Topic. While technical papers describing the author’s experience and the "know-how" details in vascular interventions are of primary interest to the Topic Editors, contributions focusing on mechanistic and therapeutic results obtained using diverse models of vascular injury are welcome. Based on their wide use in research, the rodent, rabbit, and pig models including use of genetically modified animals will be primarily presented in the collection. However, the Topic Editors encourage the submission of experimental studies in any vertebrate model of vascular injury.
Articles formatted as Original Research, Method, Review, and Mini-review will be considered for publication in this Research Topic.
Keywords: animal models, angioplasty, balloon, cardiovascular disease, ischemia, ligation, neointima, reendothelialization, remodeling, restenosis, stent, thrombosis, vascular
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
