About this Research Topic
The musculoskeletal system is an organ system that provides shape, support, and stability which enables humans to use their muscles and skeleton to move. It consists of bones, muscles, cartilage, tendons, ligaments, joints, and other connective tissue that support and bind tissues and organs together. The pathological changes in the musculoskeletal system are the main causes of disability. Because of the close relationship between the musculoskeletal system and other internal systems, these diseases may be difficult to diagnose. An in-depth understanding of the molecular regulation mechanism of musculoskeletal diseases is urgently needed, which may provide new strategies for clinical diagnosis and treatment of musculoskeletal diseases.
Recent studies suggest that disorders on the post-transcriptional level are critical factors leading to the occurrence and development of diseases. These regulatory methods include dysregulation of RNA expression (including mRNA, lncRNA, miRNA, circRNA, piRNA), methylation, acetylation, glucose metabolism, iron metabolism, etc. Certainly, these regulation modes are also critical in the physiological and pathological processes of the musculoskeletal system. We aim to encourage researchers to explore key molecules or signal pathways in the progress of musculoskeletal diseases. Through this topic, we may provide deeply understanding of the molecular pathogenesis of musculoskeletal system disease, and new biomarkers and targets for the clinical diagnosis and treatment of these diseases.
We welcome Original Research and Review articles that cover, but are not limited to:
1) The role and underlying mechanism of ncRNAs in the activities of musculoskeletal cells in musculoskeletal development, mechanotransduction, and metabolism.
2) The post-transcriptional crosstalk between the musculoskeletal organ and other organs, tissues, and systems.
3) The regulatory roles of ncRNAs, methylation, acetylation, glucose metabolism, and iron metabolism in musculoskeletal diseases (e.g. osteonecrosis, osteoporosis, osteoarthritis, osteosarcoma, amyotrophy, sarcopenia, myoatrophy).
4) Novel carriers for RNA therapies in musculoskeletal disease.
5) Novel methods for research in the field of musculoskeletal disease.
Recent studies suggest that disorders on the post-transcriptional level are critical factors leading to the occurrence and development of diseases. These regulatory methods include dysregulation of RNA expression (including mRNA, lncRNA, miRNA, circRNA, piRNA), methylation, acetylation, glucose metabolism, iron metabolism, etc. Certainly, these regulation modes are also critical in the physiological and pathological processes of the musculoskeletal system. We aim to encourage researchers to explore key molecules or signal pathways in the progress of musculoskeletal diseases. Through this topic, we may provide deeply understanding of the molecular pathogenesis of musculoskeletal system disease, and new biomarkers and targets for the clinical diagnosis and treatment of these diseases.
We welcome Original Research and Review articles that cover, but are not limited to:
1) The role and underlying mechanism of ncRNAs in the activities of musculoskeletal cells in musculoskeletal development, mechanotransduction, and metabolism.
2) The post-transcriptional crosstalk between the musculoskeletal organ and other organs, tissues, and systems.
3) The regulatory roles of ncRNAs, methylation, acetylation, glucose metabolism, and iron metabolism in musculoskeletal diseases (e.g. osteonecrosis, osteoporosis, osteoarthritis, osteosarcoma, amyotrophy, sarcopenia, myoatrophy).
4) Novel carriers for RNA therapies in musculoskeletal disease.
5) Novel methods for research in the field of musculoskeletal disease.
Keywords: Post-transcriptional regulation, ncRNAs, methylation, acetylation, glucose metabolism, iron metabolism, musculoskeletal disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
