Limbal stem cell deficiency (LSCD) is a devastating condition that contributes significantly to corneal blindness, particularly in certain regions worldwide, accounting for approximately 15% to 20% of these cases. Limbal stem cells (LSCs), located at the boundary between the corneal and conjunctival epithelium, play a crucial role in the ongoing regeneration of the corneal epithelium. This process is vital for maintaining the transparency and structural integrity of the ocular surface. The loss of LSCs due to various disease processes, such as congenital aniridia, chemical injuries, and autoimmune conditions like Stevens-Johnson syndrome, leads to severe consequences. Patients with LSCD experience persistent epithelial defects, conjunctivalization, and corneal neovascularisation, resulting in chronic pain and significant vision loss. Despite its profound impact, precise global prevalence data are scarce, with estimates largely based on single-centre studies. Recent research emphasises the need for a deeper exploration of LSCD epidemiology and effective treatment pathways.
This Research Topic aims to explore LSCD from multiple perspectives, delving into its epidemiology, pathophysiology, and emerging treatment strategies. The primary objectives include investigating the global prevalence of LSCD, assessing the effectiveness of innovative treatment methods, and testing hypotheses regarding LSC loss and regeneration mechanisms. By addressing these critical questions, the research seeks to bridge existing knowledge gaps and enhance our comprehensive understanding of LSCD, ultimately leading to better patient outcomes.
To gather further insights into the epidemiology, pathophysiology, and treatment of LSCD, we welcome contributions covering, but not limited to, the following themes:
- Epidemiology: Well-designed and adequately powered studies assessing the population prevalence of LSCD globally.
- Treatment: Case reports, case series, and retrospective analyses of outcomes using novel treatment methods and algorithms.
- Pathophysiology: Investigations into the mechanisms underlying LSC loss and regeneration.
- Clinical Management: Best practices and guidelines for diagnosing and managing LSCD.
- Innovations in Therapy: New techniques and strategies for LSC transplantation and other therapeutic interventions.
- Patient Outcomes: Long-term follow-up studies evaluating the quality of life and visual outcomes in LSCD patients.
We invite original research, reviews, and analytical studies that contribute to a holistic understanding and management of LSCD, with the ultimate goal of improving patient care and outcomes.
Keywords: limbal stem cell deficiency, cornea, epidemiology, treatment
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
