About this Research Topic
Spontaneous coronary artery dissection (SCAD) is an infrequent cause of acute coronary syndrome. SCAD is defined as a non-traumatic, non-iatrogenic spontaneous separation of the coronary artery wall. SCAD affects women more than men. Among young women, especially post-partum, SCAD is an important cause of acute myocardial infarction.
The actual cause of SCAD remains unknown. Fibromuscular dysplasia (FMD) has been raised in relationship to SCAD. The incidence of FMD in SCAD cohort varies (9-86%) among the studies since the screening methods differ. The US registry revealed that SCAD is uncommon in FMD patients; only 3.1% of FMD patients developed myocardial infarction. The true connection between SCAD and FMD remains unclear.
Genetics is one of the hot topics in SCAD and FMD patients. However, a single gene mutation or SNPs do not fully explain the pathogenesis of SCAD and FMD. Whether the genes would be beneficial for risk stratification or management is undetermined. Furthermore, the characteristics of myocardial infarction in SCAD have not been well studied.
Regardless of improvement in diagnosis and clinical management, the incidence of SCAD remains underestimated, and pathology and pathophysiology of SCAD need further understanding.
This Research Topic will investigate spontaneous coronary artery dissection, emphasizing diagnosis and management. Subtopics for this Research Topic include but are not limited to:
1. Pathology of spontaneous coronary dissection
2. Genetic studies of SCAD
3. Fibromuscular dysplasia in SCAD
4. Pathogenesis of pregnancy-associated SCAD
5. Characteristics of myocardial infarction in SCAD
The Topic Editors encourage the submission of all manuscript types which cover clinical studies, translational, and basic research of SCAD
The actual cause of SCAD remains unknown. Fibromuscular dysplasia (FMD) has been raised in relationship to SCAD. The incidence of FMD in SCAD cohort varies (9-86%) among the studies since the screening methods differ. The US registry revealed that SCAD is uncommon in FMD patients; only 3.1% of FMD patients developed myocardial infarction. The true connection between SCAD and FMD remains unclear.
Genetics is one of the hot topics in SCAD and FMD patients. However, a single gene mutation or SNPs do not fully explain the pathogenesis of SCAD and FMD. Whether the genes would be beneficial for risk stratification or management is undetermined. Furthermore, the characteristics of myocardial infarction in SCAD have not been well studied.
Regardless of improvement in diagnosis and clinical management, the incidence of SCAD remains underestimated, and pathology and pathophysiology of SCAD need further understanding.
This Research Topic will investigate spontaneous coronary artery dissection, emphasizing diagnosis and management. Subtopics for this Research Topic include but are not limited to:
1. Pathology of spontaneous coronary dissection
2. Genetic studies of SCAD
3. Fibromuscular dysplasia in SCAD
4. Pathogenesis of pregnancy-associated SCAD
5. Characteristics of myocardial infarction in SCAD
The Topic Editors encourage the submission of all manuscript types which cover clinical studies, translational, and basic research of SCAD
Keywords: Coronary Artery Dissection, Spontaneous, coronary artery disease, fibromuscular dysplasia, pathology, Pregnancy Complications, Cardiovascular
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