About this Research Topic

Submission closed

Background

In periodontal health, a balance is achieved between the oral bacteria and the host response. However, in periodontal disease, such equilibrium may easily be disrupted leading to inflammation and tissue damage. Owing to the persisting antigenic cues that trigger innate
immunogenic cells (neutrophils, monocytes, etc); the resultant proinflammatory mediators and proteolytic enzymes (e.g. MMPs) alter the expression of downstream genes involved in connective tissue and bone metabolism. If the inflammation remains unresolved, it potentiates a complex interplay between the innate and adaptive immune complex which serves as a major host destructive mechanism.

The resolution phase of chronic inflammatory immune responses in periodontitis is of great significance in determining the path of disease trajectory. Addressing periodontitis with more effective treatments can help minimize the uncertainties of secondary systemic infections.
Burgeoning evidence supports that chromatin remodeling and RNAi-mediated regulatory networks in the form of Non-Coding RNA (ncRNAs) play a central role in inflammation and control of biological changes.
Epigenetic modifications could alter genetic expression and in turn, fine-tune biological pathways and can serve to be of exemplary significance in periodontal resolution.

This Research Topic will focus on the advances in our understanding of epigenetic and noncoding RNA-based diagnostics and therapeutics in the field of immune-mediated diseases such as periodontal disease. Cutting-edge technologies that allow precise detection can
facilitate delivery in target tissues/cells and, thus be essential in monitoring the disease progression and its resolution. This Research Topic will compile current understanding in our knowledge of epigenetically mediated mechanisms (including noncoding RNAs) as potential diagnostic and therapeutic tools in the resolution of periodontal disease.

We welcome the submission of original articles (including in-vivo, ex-vivo, and in-vitro), reviews, and mini-reviews, which cover, but are not limited to, the following topics:

1. Non-coding RNA / miRNA in the regulation of immune cell signaling in the resolution
of periodontal disease
2. Transcriptional and post-transcriptional epigenetic regulation during the immune response
3. Developmental control of immune cells by epigenetic-modulated events including ncRNAs and miRNAs in periodontal inflammation and resolution
4. ncRNA regulation of immune cell polarization and plasticity in periodontal disease
5. Role of miRNAs in the resolution of periodontal disease
6. Pathogen and environmental factor-mediated epigenetic dysregulation of periodontal
disease
7. Therapeutic targeting of miRNAs in immune-mediated diseases such as periodontal
disease

Keywords: Epigenetic modulation, periodontal disease, inflammation, noncoding RNA, miRNA

Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Topic editors

juhi r uttamani
University of Iowa Health Care
Iowa City, United States

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