About this Research Topic
The aging process is complex, encompassing a myriad of changes at the cellular and systemic levels that ultimately influence organismal function and lifespan. Over the years, several key hallmarks that underpin this biological process have been identified to contribute to the progressive functional decline observed during aging collectively, namely genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. However, these hallmarks' interconnectedness and synergistic effects remain largely uncharted territory.
While these hallmarks have been individually studied, our understanding of how they interact and synergize to drive the aging process is yet to be improved. These interactions likely form a complex web, with changes in one hallmark influencing others, ultimately determining the rate and quality of aging. Unraveling this complex network is a significant challenge in geroscience and holds the key to developing effective strategies to promote healthy aging.
In this Research Topic, we aim to provide a multidimensional understanding of the hallmarks of aging, elucidating their roles and interconnections in the aging process and age-related diseases. This understanding is crucial to facilitate the development of interventions that could delay the onset of aging, enhance healthspan, and reduce the incidence of age-related diseases.
By fostering interdisciplinary dialogue and showcasing the latest research in this rapidly evolving field, we aim to stimulate new research directions and collaborations. The ultimate aspiration of this endeavor is to improve our ability to predict, monitor, and modulate the aging process, thereby enhancing the quality of life in older individuals and potentially extending healthspan.
The scope of this Research Topic extends across the spectrum of biological aging, focusing specifically on the hallmarks that underpin this intricate process. We invite contributions that deepen our understanding of these hallmarks, explore their interconnections, and elucidate their collective impact on aging and age-related diseases.
Specific Themes:
1. Underlying Mechanisms: Unraveling the cellular and molecular processes that drive each hallmark of aging and how they intersect.
2. Disease Connection: Investigating the role of these hallmarks in age-associated diseases and potential therapeutic interventions.
3. Modulating Factors: Studying the influence of environmental, lifestyle, and genetic factors on these hallmarks and the aging process.
4. Biomarkers of Aging: Identifying and validating novel biomarkers linked to these hallmarks for a more accurate assessment of biological aging.
5. Advanced Technologies: Using and developing emerging technologies, such as high-throughput sequencing, to study these hallmarks and push the boundaries of aging research.
We welcome original research articles, comprehensive reviews, opinion pieces, and perspective articles.
While these hallmarks have been individually studied, our understanding of how they interact and synergize to drive the aging process is yet to be improved. These interactions likely form a complex web, with changes in one hallmark influencing others, ultimately determining the rate and quality of aging. Unraveling this complex network is a significant challenge in geroscience and holds the key to developing effective strategies to promote healthy aging.
In this Research Topic, we aim to provide a multidimensional understanding of the hallmarks of aging, elucidating their roles and interconnections in the aging process and age-related diseases. This understanding is crucial to facilitate the development of interventions that could delay the onset of aging, enhance healthspan, and reduce the incidence of age-related diseases.
By fostering interdisciplinary dialogue and showcasing the latest research in this rapidly evolving field, we aim to stimulate new research directions and collaborations. The ultimate aspiration of this endeavor is to improve our ability to predict, monitor, and modulate the aging process, thereby enhancing the quality of life in older individuals and potentially extending healthspan.
The scope of this Research Topic extends across the spectrum of biological aging, focusing specifically on the hallmarks that underpin this intricate process. We invite contributions that deepen our understanding of these hallmarks, explore their interconnections, and elucidate their collective impact on aging and age-related diseases.
Specific Themes:
1. Underlying Mechanisms: Unraveling the cellular and molecular processes that drive each hallmark of aging and how they intersect.
2. Disease Connection: Investigating the role of these hallmarks in age-associated diseases and potential therapeutic interventions.
3. Modulating Factors: Studying the influence of environmental, lifestyle, and genetic factors on these hallmarks and the aging process.
4. Biomarkers of Aging: Identifying and validating novel biomarkers linked to these hallmarks for a more accurate assessment of biological aging.
5. Advanced Technologies: Using and developing emerging technologies, such as high-throughput sequencing, to study these hallmarks and push the boundaries of aging research.
We welcome original research articles, comprehensive reviews, opinion pieces, and perspective articles.
Keywords: Aging Hallmarks, Cellular Senescence, Epigenetic Alterations, Proteostasis, Geroscience.
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
