About this Research Topic
In recent years, the increase in knowledge about the functioning of the immune system has revealed not only its importance in the defense against external agents such as pathogens or toxins, but also in the control of tumor cells and the importance of the processes of inflammation or immunological tolerance. On the one hand, all this knowledge has allowed a better understanding of the putative pathogenic consequences of immune system dysfunction, which includes inflammatory, autoimmune and immunosuppressive diseases, among others. On the other hand, current knowledge about immunoregulation has paved the way to better prevent or control transplantation rejection. However, such mechanisms underlying immune dysregulation are highly variable depending on the type of pathology (systemic chronic inflammatory diseases, autoinflammatory diseases, autoimmune disorders, immunosuppression) and on characteristics of the host such as sex, genetics, nutritional status, etc. Given the wide variety of pathologies that are a consequence of excessive, inefficient or inadequate induction of immune responses, the study of factors involved in the dysregulation of the immune system has gained great attention during the last decades.
Despite the significant advance in our current understanding of the immune system biology achieved during the last decades, several aspects of the cellular and molecular mechanisms underlying the development of diseases associated with immune dysregulation remain to be unveiled. Thus, further insights into the consequences of various processes that disrupt the immune system are needed. Likewise, research focused on the interplay between immune dysregulation and factors such as age, sex, environment, past infections, and other environmental factors will likely pave the way to the development of targeted and effective therapies to more efficiently treat these conditions.
This research topic aims to broaden our current understanding of the molecular mechanism related to immune system dysfunctions, their consequences, and their impact on the development of various pathologies and their clinical implications.
We welcome the submission of Original Research, Review and Mini-Review articles, which cover, but are not limited to, the following topics:
- Description of the mechanism involved in the development of autoimmune diseases, allergic diseases, or autoinflammatory disorders.
- Mechanisms leading to immunosuppression or immunodeficiency (primary or secondary).
- Studies examining potential links between genetics, epigenetics, and the microbiota in disorders of the immune system
- Immune system failures and their relationship with dementia or cancer.
- Different clinical presentations of diseases related to immune deregulations. Proposed mechanism and link to environmental agents and/or pathogens.
- Development of therapeutic approaches based on immunomodulation.
Despite the significant advance in our current understanding of the immune system biology achieved during the last decades, several aspects of the cellular and molecular mechanisms underlying the development of diseases associated with immune dysregulation remain to be unveiled. Thus, further insights into the consequences of various processes that disrupt the immune system are needed. Likewise, research focused on the interplay between immune dysregulation and factors such as age, sex, environment, past infections, and other environmental factors will likely pave the way to the development of targeted and effective therapies to more efficiently treat these conditions.
This research topic aims to broaden our current understanding of the molecular mechanism related to immune system dysfunctions, their consequences, and their impact on the development of various pathologies and their clinical implications.
We welcome the submission of Original Research, Review and Mini-Review articles, which cover, but are not limited to, the following topics:
- Description of the mechanism involved in the development of autoimmune diseases, allergic diseases, or autoinflammatory disorders.
- Mechanisms leading to immunosuppression or immunodeficiency (primary or secondary).
- Studies examining potential links between genetics, epigenetics, and the microbiota in disorders of the immune system
- Immune system failures and their relationship with dementia or cancer.
- Different clinical presentations of diseases related to immune deregulations. Proposed mechanism and link to environmental agents and/or pathogens.
- Development of therapeutic approaches based on immunomodulation.
Keywords: Immune system disorders, dysfunction, autoimmune diseases, autoinflammatory diseases, immunodeficiency, immunosuppression, immune therapy, Immune modulation
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
