About this Research Topic
With the recent shift of emphasis from short-term to long-term transplant outcomes, there has been a renewed interest in how the innate immune system regulates transplant survival, an area that is traditionally dominated by the adaptive immune cells, especially T cells. This shift is driven primarily by the inability of current immune suppression drugs, which mostly target T cells, in preventing chronic allograft loss, as well as the rapid advance of basic science and new technologies in the area of innate immunity. In fact, the innate immune cells have emerged as key players in the allograft response in various models, contributing to both graft rejection and graft acceptance, thus providing new therapeutic opportunities in further improvement of transplant outcomes.
This research topic is intended to debate and discuss new developments regarding how innate immune mechanisms influence transplant outcomes in preclinical models and clinical settings, to highlight new therapeutic approaches in targeting the innate responses, and to pinpoint ongoing challenges and unresolved questions for future studies.
The scope of this research topic includes, but not limited to the following:
1. Mechanisms of tissue inflammation and the resolution of inflammation.
2. Innate sensors, innate cells, and their activation, regulation, and dysregulation.
3. Innate immune responses, innate memory and fundamental mechanisms involved.
4. Adaptive immune cells with "innate-like" features, their generation, function, and regulation.
5. Innate responses at barrier surfaces and their impact on system immunity and graft outcomes.
6. Translational studies of innate immune cells in clinical settings.
This research topic is intended to debate and discuss new developments regarding how innate immune mechanisms influence transplant outcomes in preclinical models and clinical settings, to highlight new therapeutic approaches in targeting the innate responses, and to pinpoint ongoing challenges and unresolved questions for future studies.
The scope of this research topic includes, but not limited to the following:
1. Mechanisms of tissue inflammation and the resolution of inflammation.
2. Innate sensors, innate cells, and their activation, regulation, and dysregulation.
3. Innate immune responses, innate memory and fundamental mechanisms involved.
4. Adaptive immune cells with "innate-like" features, their generation, function, and regulation.
5. Innate responses at barrier surfaces and their impact on system immunity and graft outcomes.
6. Translational studies of innate immune cells in clinical settings.
Keywords: Innate immunity, Inflammation, Rejection, Allograft tolerance, Immune memory
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
